Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13411417 | 0.98 | HTT (0.49) | HTTPPARDTSHR | |
| Bromide SCHEMBL31354627 | 0.89 | MEN1 (0.46) | HTTPPARDMEN1MAPTKMT2A | |
| SCHEMBL14929645 | 0.84 | HTT (0.47) | HTTMEN1GLAMAPTMAPK1 | |
| SCHEMBL17817524 | 0.78 | GGPS1 (0.48) | HTTMEN1MAPTKMT2ASMN1; SMN2 | |
| Bromide SCHEMBL193632 | 0.70 | HTT (0.79) | HTTMEN1MAPTMAPK1KMT2A | |
| Bromide SCHEMBL30903821 | 0.70 | HTT (0.78) | HTTMEN1MAPTKMT2A | |
| Bromide SCHEMBL26090899 | 0.70 | HTT (0.78) | HTTMEN1MAPTKMT2A | |
| SCHEMBL5017294 | 0.70 | PPARD (0.64) | PPARDTSHR | |
| SCHEMBL7268189 | 0.70 | PPARD (0.64) | PPARDTSHR | |
| SCHEMBL18234751 | 0.70 | HTT (0.70) | HTTMEN1MAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2982245-B1 | CYANINE DYES FOR LABELING OF TARGET MOLECULES, IDENTIFICATION OF ORGANELLES AND OTHER APPLICATIONS | ENZO LIFE SCIENCES INC (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-2982245-A1 | LABELING OF TARGET MOLECULES, IDENTIFICATION OF ORGANELLES AND OTHER APPLICATIONS, NOVEL COMPOSITIONS, METHODS AND KITS | Enzo Life Sciences, Inc. (US) | 2016-02-10 | — | — | EP | disclosed |
| EP-2381783-B1 | LABELING OF TARGET MOLECULES, IDENTIFICATION OF ORGANELLES AND OTHER APPLICATIONS, NOVEL COMPOSITIONS, METHODS AND KITS | ENZO LIFE SCIENCES INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-8674102-B2 | Fluorescent dyes | ENZO LIFE SCIENCES, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8604204-B2 | Fluorescent dyes | ENZO LIFE SCIENCES, INC. (US) | 2013-12-10 | — | — | US | disclosed |
| US-20130217059-A1 | FLUORESCENT DYES | ENZO LIFE SCIENCES, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-20130209994-A1 | FLUORESCENT DYES | ENZO LIFE SCIENCES, INC. (US) | 2013-08-15 | — | — | US | disclosed |
| US-8476443-B2 | Fluorescent dyes | ENZO LIFE SCIENCES, INC. (US) | 2013-07-02 | — | — | US | disclosed |
| US-20130115651-A1 | FLUORESCENT DYES | ENZO BIOCHEM, INC. (US) | 2013-05-09 | — | — | US | disclosed |
| US-8362250-B2 | Fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest | ENZO BIOCHEM, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-8357801-B2 | Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits | ENZO LIFE SCIENCES, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| EP-2381783-A1 | LABELING OF TARGET MOLECULES, IDENTIFICATION OF ORGANELLES AND OTHER APPLICATIONS, NOVEL COMPOSITIONS, METHODS AND KITS | Enzo Life Sciences, Inc. (US) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010065918-A1 | LABELING OF TARGET MOLECULES, IDENTIFICATION OF ORGANELLES AND OTHER APPLICATIONS, NOVEL COMPOSITIONS, METHODS AND KITS | ENZO LIFE SCIENCES, INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| US-20100068752-A1 | Novel fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest | ENZO LIFE SCIENCES, INC. | 2010-03-18 | — | — | US | disclosed |
| US-20090226954-A1 | Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits | ENZO LIFE SCIENCES, INC. | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090226954-A1 | Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits | SSBP1, IMMT, DNAJA3 | HTT 993/4885PPARD 2987/4885MEN1 3282/4885 |
| US-20130115651-A1 | FLUORESCENT DYES | ANXA5, SSBP1, IARS1 | HTT 539/4885PPARD 3092/4885MEN1 3539/4885 |
| US-20100068752-A1 | Novel fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest | SSBP1, YARS1, ANXA5 | HTT 672/4885PPARD 2600/4885MEN1 3286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.