IARS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL117553	1.00	10/20
SCHEMBL6510822	0.51	7/20
SCHEMBL8670080	0.45	7/20
SCHEMBL3634255	0.57	6/20
SCHEMBL3635284	0.57	6/20
SCHEMBL3665648	0.53	6/20
SCHEMBL19361328	0.41	6/20
SCHEMBL11413095	0.91	5/20
SCHEMBL11060280	0.84	5/20
SCHEMBL19532799	0.84	5/20
SCHEMBL4995687	0.80	5/20
SCHEMBL19541395	0.73	5/20
SCHEMBL116374	0.73	5/20
SCHEMBL117518	0.73	5/20
SCHEMBL19183739	0.72	5/20
SCHEMBL974341	0.69	5/20
SCHEMBL14616862	0.69	5/20
SCHEMBL14045603	0.66	5/20
SCHEMBL3665421	0.62	5/20
SCHEMBL11062889	0.58	5/20

Clinical trials — most relevant to IARS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment	PHASE2/PHASE3	COMPLETED
HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes	PHASE2	RECRUITING
Reverse Transcriptase Inhibitors in AGS	PHASE2	COMPLETED
Cholic Acid for Hepatic Steatosis in Lipodystrophy	PHASE2	COMPLETED
Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST	PHASE2	COMPLETED
Effects of Cannabidiol (CBD) on the Activation of Autophagy and Inflammation Genes, Functional Consequences in Virologically Controlled HIV-infected Patients	PHASE2	COMPLETED
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
Impact of Seasonal Malaria Chemoprevention on Immunity Against Malaria Among Children in Northern Benin	nan	COMPLETED
Genomic of CONgenital Sideroblastic Anemias	nan	RECRUITING
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy	nan	COMPLETED
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Mitoquines in COPD	nan	UNKNOWN
Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)	nan	RECRUITING
Epidemiology of Atherosclerosis	nan	COMPLETED
Fatty Acid Oxidation Defects and Insulin Sensitivity	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Genetic and Metabolic Disease in Children	nan	RECRUITING
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
The Role of Ectopic Fat and Heart Attack Risk in HIV	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a IARS1 binder may also engage these)

Protein	Name	Similarity
Q8BU30	—	1.000	Q8BU30 →
B0B9C6	—	0.999	B0B9C6 →
Q3ZZG9	—	0.996	Q3ZZG9 →
O83466	—	0.996	O83466 →
Q2FPJ4	—	0.996	Q2FPJ4 →
Q5GSS3	—	0.995	Q5GSS3 →
Q9Z972	—	0.995	Q9Z972 →
Q9PL20	—	0.995	Q9PL20 →
Q255D3	—	0.995	Q255D3 →
Q6FZB1	—	0.994	Q6FZB1 →
O84304	—	0.994	O84304 →
B2S348	—	0.994	B2S348 →
F4JLM5	—	0.994	F4JLM5 →
Q5L5J6	—	0.994	Q5L5J6 →
Q5L5L0	—	0.994	Q5L5L0 →
Q73HW7	—	0.994	Q73HW7 →
Q6MQK8	—	0.994	Q6MQK8 →
Q822L8	—	0.993	Q822L8 →
O84022	—	0.993	O84022 →
Q3Z7P5	—	0.993	Q3Z7P5 →
B0BBT3	—	0.993	B0BBT3 →
P36422	—	0.993	P36422 →
B0BB05	—	0.993	B0BB05 →
Q1RIY1	—	0.993	Q1RIY1 →
B0B7L8	—	0.993	B0B7L8 →
Q8TN62	—	0.993	Q8TN62 →
Q3ZY20	—	0.993	Q3ZY20 →
Q82X51	—	0.993	Q82X51 →
Q5L5Q6	—	0.993	Q5L5Q6 →
Q12ZD1	—	0.993	Q12ZD1 →