Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2574177 | 0.89 | GRM5 (0.38) | TRPV1 | |
| SCHEMBL2564173 | 0.86 | AVPR2 (0.31) | CYP11B2 | |
| SCHEMBL2556274 | 0.83 | CYP11B2 (0.32) | TRPV1CYP11B2CYP11B1 | |
| SCHEMBL2564864 | 0.76 | AVPR2 (0.37) | CYP11B2 | |
| SCHEMBL2580101 | 0.75 | HDAC2 (0.34) | — | |
| SCHEMBL2561657 | 0.73 | CYP11B1 (0.32) | CYP11B2CYP11B1 | |
| SCHEMBL2549529 | 0.72 | AVPR2 (0.35) | — | |
| SCHEMBL2573984 | 0.72 | HSD11B1 (0.35) | — | |
| SCHEMBL2556595 | 0.72 | CYP11B2 (0.32) | CYP11B2 | |
| SCHEMBL2556524 | 0.70 | CYP11B2 (0.32) | CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558467-A1 | ARYL - /HETEROARYL - CYCLOHEXENYL - TETRAAZABENZO [E]AZULENES AS VASOPRESSIN ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011128265-A1 | ARYL - /HETEROARYL - CYCLOHEXENYL - TETRAAZABENZO [E] AZULENES AS VASOPRESSIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-20 | — | — | WO | disclosed |