Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25725161 | 0.89 | AURKA (0.47) | HTTALDH1A1AURKAKITACHE | |
| SCHEMBL25229702 | 0.84 | AKT1 (0.44) | AURKAKIT | |
| SCHEMBL25630561 | 0.84 | KIT (0.41) | HTTALDH1A1AURKAKITACHE | |
| SCHEMBL31501711 | 0.84 | HTT (0.44) | HTTALDH1A1AURKAKITPRMT5 | |
| SCHEMBL25227852 | 0.84 | HTT (0.44) | HTTALDH1A1AURKAKITPRMT5 | |
| SCHEMBL25633236 | 0.83 | HTT (0.52) | HTTNPSR1ALDH1A1AURKAACHE | |
| SCHEMBL31501613 | 0.83 | ACHE (0.42) | HTTAURKAACHEBACE1MEN1 | |
| SCHEMBL25270731 | 0.81 | MEN1 (0.47) | HTTAURKAKITACHEBACE1 | |
| SCHEMBL31501642 | 0.81 | MEN1 (0.47) | HTTAURKAKITACHEBACE1 | |
| SCHEMBL25270732 | 0.81 | MEN1 (0.47) | HTTAURKAKITACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107687-A1 | INHIBITORS OF MENIN-MLL INTERACTION | BALA THERAPEUTICS, INC. (US) | 2023-06-15 | — | — | WO | disclosed |