Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1491198 | 0.85 | CHRNB2 (0.46) | CHRNB2CHRNB4CHRNA3CHRNA4HPGD | |
| SCHEMBL24767635 | 0.82 | CHRNB2 (0.48) | CHRNB2CHRNB4CHRNA3CHRNA4HPGD | |
| SCHEMBL18325693 | 0.82 | HPGD (0.66) | CHRNB2CHRNB4CHRNA3CHRNA4HPGD | |
| SCHEMBL11212470 | 0.82 | LARS1 (0.48) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A | |
| SCHEMBL1139982 | 0.80 | MLYCD (0.54) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A | |
| SCHEMBL25527598 | 0.80 | SMN1; SMN2 (0.54) | CHRNB2CHRNB4CHRNA3CHRNA4HPGD | |
| SCHEMBL28997151 | 0.80 | CYP2C19 (0.44) | CHRNB2CHRNB4CHRNA3CHRNA4HPGD | |
| SCHEMBL1819686 | 0.80 | TSHR (0.55) | CHRNB2CHRNB4CHRNA3CHRNA4HPGD | |
| SCHEMBL13831220 | 0.77 | KMT2A (0.46) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A | |
| SCHEMBL7497496 | 0.77 | KMT2A (0.46) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11679090-B2 | Modulators of Sestrin-GATOR2 interaction and uses thereof | NAVITOR PHARMACEUTICALS, INC. (US) | 2023-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11679090-B2 | Modulators of Sestrin-GATOR2 interaction and uses thereof | GATD3, GABRR2, GABRR3 | CHRNB2 1143/4885CHRNB4 1477/4885CHRNA3 1985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.