Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25056359 | 0.88 | PKM (0.38) | PKMTDP1SMN1; SMN2SIRT6ALDH1A1 | |
| SCHEMBL25056453 | 0.85 | CCNT1 (0.34) | PKMTDP1GPR119CCNT1CDK9 | |
| SCHEMBL25637760 | 0.85 | PKM (0.38) | PKMTDP1SMN1; SMN2SIRT6ALDH1A1 | |
| SCHEMBL25056290 | 0.85 | GPR119 (0.38) | GPR119CCNT1CDK9ALDH1A1MAPT | |
| SCHEMBL25637675 | 0.82 | SMN1; SMN2 (0.36) | CHRM4DRD2HTR7GPR119SMN1; SMN2 | |
| SCHEMBL25637878 | 0.82 | BTK (0.38) | GPR119CCNT1CDK9USP30ALDH1A1 | |
| SCHEMBL25637647 | 0.82 | SIRT6 (0.39) | PKMTDP1SMN1; SMN2SIRT6ALDH1A1 | |
| SCHEMBL25642368 | 0.80 | SIRT6 (0.34) | PKMTDP1SMN1; SMN2SIRT6ALDH1A1 | |
| SCHEMBL25637694 | 0.79 | ALDH1A1 (0.38) | PKMTDP1SMN1; SMN2SIRT6ALDH1A1 | |
| SCHEMBL25637666 | 0.79 | TDP1 (0.40) | PKMTDP1SMN1; SMN2SIRT6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192734-A1 | TRICYCLIC COMPOUNDS AS EGFR INHIBITORS | QILU PHARMACEUTICAL CO LTD (CN) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192734-A1 | TRICYCLIC COMPOUNDS AS EGFR INHIBITORS | EGFR, ERBB2, ERBB3 | CHRM4 4876/4885DRD2 4440/4885HTR7 2407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.