Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24190070 | 0.94 | SIGMAR1 (0.55) | SIGMAR1CYP1A2DPP4DNM1MEN1 | |
| SCHEMBL19806839 | 0.89 | DNM1 (0.48) | SIGMAR1CYP1A2DPP4DNM1MEN1 | |
| SCHEMBL22260597 | 0.87 | SIGMAR1 (0.67) | SIGMAR1DNM1TSHREPHX1CA1 | |
| SCHEMBL19339159 | 0.85 | CYP1A2 (0.50) | SIGMAR1CYP1A2DPP4MEN1KMT2A | |
| SCHEMBL23742068 | 0.84 | SIGMAR1 (0.62) | SIGMAR1DNM1MEN1KMT2ATSHR | |
| SCHEMBL28286303 | 0.84 | CYP1A2 (0.59) | CYP1A2DPP4MEN1KMT2AALDH1A1 | |
| SCHEMBL27603789 | 0.82 | CYP1A2 (0.52) | SIGMAR1CYP1A2DPP4ALDH1A1TSHR | |
| SCHEMBL11254008 | 0.82 | CYP1A2 (0.52) | SIGMAR1CYP1A2DPP4ALDH1A1TSHR | |
| SCHEMBL28485961 | 0.82 | CYP1A2 (0.50) | CYP1A2DPP4MEN1KMT2AALDH1A1 | |
| SCHEMBL21844988 | 0.81 | CYP1A2 (0.52) | CYP1A2DPP4ALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192712-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192712-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | SIGMAR1 2741/4885CYP1A2 2965/4885DPP4 3362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.