Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | MITF | O75030 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SNCA | P37840 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12218430 | 0.87 | NPC1 (0.67) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL2564961 | 0.85 | NPC1 (0.71) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL825718 | 0.85 | NPC1 (0.63) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL17660220 | 0.84 | PTPN1 (0.67) | RAB9ANPC1SMN1; SMN2ALDH1A1PTPN1 | |
| SCHEMBL7299664 | 0.84 | NR1H4 (0.68) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL2564458 | 0.83 | RAB9A (0.62) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL4182502 | 0.82 | ROCK2 (0.68) | RAB9ANPC1SMN1; SMN2TP53PTPN1 | |
| SCHEMBL4182497 | 0.82 | ROCK2 (0.68) | RAB9ANPC1SMN1; SMN2TP53PTPN1 | |
| SCHEMBL12630758 | 0.82 | MEN1 (0.57) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL13851187 | 0.82 | NPC1 (0.56) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382194-A2 | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE | RESVERLOGIX CORP. (CA) | 2011-11-02 | — | — | EP | disclosed |