Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.68 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.63 |
| ▸ | MITF | O75030 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | NOS1 | P29475 | 1/20 | 0.57 |
| ▸ | NOS2 | P35228 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | SNCA | P37840 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4182497 | 1.00 | ROCK2 (0.68) | ROCK2ROCK1PTPN1MITFRAB9A | |
| SCHEMBL17660220 | 0.87 | PTPN1 (0.67) | PTPN1MITFRAB9ANPC1ATM | |
| SCHEMBL14846601 | 0.84 | ROCK2 (0.72) | ROCK2ROCK1PTPN1RAB9ANPC1 | |
| SCHEMBL10684470 | 0.83 | PTPN1 (0.88) | PTPN1MITFRAB9ANPC1ATM | |
| Hydrochloric Acid SCHEMBL19177744 | 0.83 | ROCK2 (0.73) | ROCK2ROCK1PTPN1RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL19177742 | 0.83 | ROCK2 (0.73) | ROCK2ROCK1PTPN1RAB9ANPC1 | |
| SCHEMBL2564673 | 0.82 | RAB9A (0.60) | PTPN1MITFRAB9ANPC1ATM | |
| SCHEMBL1553349 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1RAB9ANPC1MEN1 | |
| SCHEMBL1554113 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1RAB9ANPC1MEN1 | |
| SCHEMBL1553353 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090004185-A1 | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF BETA-CATENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS | WYETH (US) | 2009-01-01 | — | — | US | disclosed |
| WO-2008086462-A2 | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS | WYETH (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090004185-A1 | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF BETA-CATENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS | TCF4, CTNNB1, TCF7 | ROCK2 3617/4885ROCK1 3547/4885PTPN1 2569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.