Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MPL | P40238 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32679848 | 0.98 | ALDH1A1 (0.39) | ALDH1A1GAAKMT2APOLBKDM4E | |
| SCHEMBL360272 | 0.98 | ALDH1A1 (0.39) | ALDH1A1GAAKMT2APOLBKDM4E | |
| Potassium SCHEMBL2564722 | 0.96 | ALDH1A1 (0.38) | ALDH1A1GAAKMT2APOLBKDM4E | |
| SCHEMBL24278496 | 0.82 | ALDH1A1 (0.39) | ALDH1A1GAAKMT2APOLBKDM4E | |
| SCHEMBL8959215 | 0.79 | ALDH1A1 (0.42) | ALDH1A1GAAKMT2APOLBKDM4E | |
| SCHEMBL3775205 | 0.78 | KDM4E (0.52) | ALDH1A1KMT2APOLBKDM4EMEN1 | |
| SCHEMBL2840799 | 0.77 | HPGD (0.34) | ALDH1A1KMT2AKDM4EMEN1MAPT | |
| SCHEMBL18066938 | 0.77 | LMNA (0.50) | ALDH1A1GAAPOLBRECQLCASP6 | |
| SCHEMBL197382 | 0.77 | RAD51 (0.41) | HSD17B10TSHRHIF1ALMNAHPGD | |
| SCHEMBL11327329 | 0.77 | MYC (0.41) | ALDH1A1GAAKMT2APOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844088-B2 | Process for the preparation of estetrol | ESTETRA SPRL (BE) | 2020-11-24 | — | — | US | disclosed |
| US-20170369521-A1 | PROCESS FOR THE PREPARATION OF ESTETROL | DONESTA BIOSCIENCE B.V. (NL) | 2017-12-28 | — | — | US | disclosed |
| EP-2734536-B1 | PROCESS FOR THE PREPARATION OF ESTETROL | DONESTA BIOSCIENCE B V (NL) | 2016-09-28 | — | — | EP | disclosed |
| US-20140235882-A1 | PROCESS FOR THE PREPARATION OF ESTETROL | Pantarhei Biocience B.V. | 2014-08-21 | — | — | US | disclosed |
| EP-2734536-A1 | PROCESS FOR THE PREPARATION OF ESTETROL | Pantarhei Bioscience B.V. (NL) | 2014-05-28 | — | — | EP | disclosed |
| WO-2013012328-A1 | PROCESS FOR THE PREPARATION OF ESTETROL | PANTARHEI BIOSCIENCE B.V. (NL) | 2013-01-24 | — | — | WO | disclosed |
| EP-2383279-A1 | Process for the preparation of estetrol | Pantarhei Bioscience B.V. (NL) | 2011-11-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170369521-A1 | PROCESS FOR THE PREPARATION OF ESTETROL | HSD17B11, CYP19A1, SULT1A1 | ALDH1A1 685/4885GAA 3681/4885KMT2A 1566/4885 |
| US-10844088-B2 | Process for the preparation of estetrol | HSD17B11, CYP19A1, SULT1A1 | ALDH1A1 511/4885GAA 3636/4885KMT2A 1356/4885 |
| US-20140235882-A1 | PROCESS FOR THE PREPARATION OF ESTETROL | CYP19A1, HSD17B11, SULT1A1 | ALDH1A1 335/4885GAA 3495/4885KMT2A 1392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.