Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.52 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | XIAP | P98170 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | CPA3 | P15088 | 3/20 | 0.47 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.46 |
| ▸ | CPA1 | P15085 | 2/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | CPB1 | P15086 | 1/20 | 0.46 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376371 | 0.91 | CNR2 (0.46) | CYP1A2MDM2MMP8CPA3CPA1 | |
| SCHEMBL28140267 | 0.89 | MDM2 (0.49) | CYP1A2MDM2ALPIPKMPTGS1 | |
| SCHEMBL1522685 | 0.85 | MMP8 (0.64) | MDM2PKMMMP8KDM4EMEN1 | |
| SCHEMBL7239119 | 0.85 | CYP1A2 (0.55) | CYP1A2MDM2ALPIPKMPTGS1 | |
| SCHEMBL973510 | 0.84 | HPGD (0.46) | CPA1POLBKMT2ATDP1LDHA | |
| SCHEMBL7581741 | 0.83 | KEAP1 (0.61) | CYP1A2MDM2ALPIPKMPTGS1 | |
| SCHEMBL27560753 | 0.82 | MDM2 (0.42) | CYP1A2MDM2ALPIPKMPTGS1 | |
| SCHEMBL8904082 | 0.82 | PRSS1 (0.50) | CYP1A2MMP8MEN1CYP2C9CYP2C19 | |
| SCHEMBL8039405 | 0.82 | LDHA (0.73) | LDHA | |
| SCHEMBL6121990 | 0.81 | CYP1A2 (0.47) | CYP1A2MDM2ALPIPKMPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104592181-B | 2-fluorine polysubstituted 4H-pyran derivate and preparation method thereof | 华东师范大学 | 2016-08-24 | — | — | CN | disclosed |
| CN-104592181-A | 2-fluoro-polysubstituted-4H-pyran derivatives and preparation method thereof | UNIV EAST CHINA NORMAL | 2015-05-06 | — | — | CN | disclosed |
| EP-2382205-B1 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS | SANOFI SA (FR) | 2014-04-23 | — | — | EP | disclosed |
| EP-2382205-A2 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS | SANOFI (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010076524-A2 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS | SANOFI-AVENTIS (FR) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010015657-A2 | NEW ALKOXYPYRAZOLES | INSTITUT PASTEUR (FR) | 2010-02-11 | — | — | WO | disclosed |
| EP-2151433-A1 | Alkoxypyrazoles and the process for their preparation | Institut Pasteur (FR) | 2010-02-10 | — | — | EP | disclosed |
| US-7642073-B2 | Using mixture comprising modified alcohol dehydrogenase, ammonia, nicotinamide and 2-ketoacid to generate preferential amino acids | CODEXIS, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-20080076162-A1 | Using mixture comprising modified alcohol dehydrogenase, ammonia, nicotinamide and 2-ketoacid to generate preferential amino acids | BIOCATALYTICS, INC. | 2008-03-27 | — | — | US | disclosed |
| US-7202070-B2 | Generating phenylalanine and leucine using mutant enzymatic polypeptide; generate mutant enzyme, aminate ketoacid, recover amino acids | BIOCATALYTICS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20020061564-A1 | Generating phenylalanine and leucine using mutant enzymatic polypeptide; generate mutant enzyme, aminate ketoacid, recover amino acids | CODEXIS, INC. | 2002-05-23 | — | — | US | disclosed |
| WO-2002036742-A2 | METHOD FOR CHEMICAL TRANSFORMATION USING A MUTATED ENZYME | BIOCATALYTICS, INC. (US) | 2002-05-10 | — | — | WO | disclosed |
| EP-0900230-B1 | ESCULETIN DERIVATIVES | IDG UK LTD (GB) | 2001-12-12 | — | — | EP | disclosed |
| US-6287798-B1 | COMPOUND WHICH IS HYDROLYZABLE BY MICROORGANISMS FOR DETECTION IN SAMPLES; FORMS BLACK, INSOLUBLE, NONDIFFUSABLE COMPOUND | IDG (UK) LIMITED (GB) | 2001-09-11 | — | — | US | disclosed |
| US-6008008-A | 6- OR 7-SUBSTITUTED DERIVATIVES WHICH ARE MICROBIALLY HYDROLYZABLE TO FLUORESCENT, IRON CHELATING MOIETIES WHICH ARE NONDIFFUSING IN AGAR AND OTHER AQUEOUS ENVIRONMENTS; FOR DETECTION OF MICROORGANISMS | IDG (UK) LIMITED (GB) | 1999-12-28 | — | — | US | disclosed |
| US-5800897-A | Air freshener composition containing a fiber pad | EASTMAN CHEMICAL COMPANY (US) | 1998-09-01 | — | — | US | disclosed |
| EP-0506478-B1 | Piperidine derivatives | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| WO-1997026926-A1 | AIR FRESHENER COMPOSITION CONTAINING A FIBER PAD | EASTMAN CHEMICAL COMPANY (US) | 1997-07-31 | — | — | WO | disclosed |
| US-5250542-A | Prevention of side effects induced by narcotics used as analgesics such as constipation, nausea and vomiting; 1-carboxyalkyl-4-methyl-4-(3-oxyphenyl)piperidines such as alvimopan | ELI LILLY AND COMPANY (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0506478-A1 | Piperidine derivatives | ELI LILLY AND COMPANY (US) | 1992-09-30 | — | — | EP | disclosed |