Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 9/20 | 0.46 |
| ▸ | BACE1 | P56817 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18767066 | 0.84 | BCHE (0.63) | BCHEBACE1 | |
| SCHEMBL6694692 | 0.81 | DNM1 (0.54) | BCHELMNADNM1 | |
| SCHEMBL5219603 | 0.81 | DNM1 (0.54) | BCHELMNADNM1 | |
| SCHEMBL5392678 | 0.81 | CETP (0.50) | BCHEBACE1CETPDNM1 | |
| SCHEMBL257187 | 0.78 | BACE1 (0.49) | BCHEBACE1 | |
| SCHEMBL5216600 | 0.78 | BACE1 (0.49) | BCHEBACE1LMNA | |
| SCHEMBL168266 | 0.76 | DNM1 (0.62) | BCHEDNM1 | |
| SCHEMBL5930107 | 0.73 | SMN1; SMN2 (0.48) | BCHELMNADNM1 | |
| SCHEMBL13333754 | 0.73 | BACE1 (0.45) | BCHEBACE1 | |
| SCHEMBL5930378 | 0.71 | CYP1A2 (0.56) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |