Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.50 |
| ▸ | CA1 | P00915 | 8/20 | 0.50 |
| ▸ | CA9 | Q16790 | 6/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 5/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 3/20 | 0.39 |
| ▸ | TDO2 | P48775 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL784140 | 0.87 | CA1 (0.51) | CA2CA1CA9MAPK1CA12 | |
| Hydrochloric Acid SCHEMBL29970039 | 0.81 | CA2 (0.53) | CA2CA1CA9MAPK1CA12 | |
| SCHEMBL12474849 | 0.76 | CA1 (0.47) | CA2CA1CA9MAPK1LMNA | |
| SCHEMBL28216449 | 0.76 | CA2 (0.47) | CA2CA1CA9MAPK1CA12 | |
| SCHEMBL29718566 | 0.76 | CA2 (0.47) | CA2CA1CA9MAPK1CA12 | |
| SCHEMBL8514484 | 0.75 | CA2 (0.50) | CA2CA1CA9MAPK1CA12 | |
| SCHEMBL6292017 | 0.75 | CA2 (0.46) | CA2CA1CA9MAPK1CA12 | |
| SCHEMBL5018093 | 0.75 | EDNRA (0.53) | CA2CA1CA9MAPK1CA12 | |
| SCHEMBL1990221 | 0.74 | LRRK2 (0.49) | CA2CA1CA9LRRK2CA12 | |
| SCHEMBL29442129 | 0.74 | LRRK2 (0.49) | CA2CA1CA9LRRK2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884046-A | chemical compounds as inhibitors of kinase activity | 葛兰素史克知识产权开发有限公司 | 2018-11-23 | — | — | CN | disclosed |
| EP-2382215-A1 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010076525-A1 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-07-08 | — | — | WO | disclosed |