Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.46 |
| ▸ | CA1 | P00915 | 12/20 | 0.46 |
| ▸ | CA9 | Q16790 | 12/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 11/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8514484 | 0.81 | CA2 (0.50) | CA2CA1CA9MAPK1CA12 | |
| SCHEMBL30114413 | 0.79 | ALOX5AP (0.49) | CA2CA1CA9MAPK1CA12 | |
| SCHEMBL4669011 | 0.79 | ALOX5AP (0.49) | CA2CA1CA9MAPK1CA12 | |
| Hydrochloric Acid SCHEMBL29970039 | 0.77 | CA2 (0.53) | CA2CA1CA9MAPK1CA12 | |
| SCHEMBL2565634 | 0.75 | CA2 (0.50) | CA2CA1CA9MAPK1CA12 | |
| SCHEMBL8891958 | 0.74 | PIEZO1 (0.40) | LMNACYP2A6KDM4ENPC1 | |
| SCHEMBL784140 | 0.73 | CA1 (0.51) | CA2CA1CA9MAPK1CA12 | |
| SCHEMBL28587100 | 0.71 | SIRT3 (0.47) | CYP2A6KDM4ENPC1HPGDALDH1A1 | |
| SCHEMBL29604515 | 0.70 | PIEZO1 (0.40) | CYP2A6NPC1HPGD | |
| SCHEMBL30567475 | 0.70 | TRIM24 (0.46) | LMNACYP2A6KDM4ENPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6943254-B2 | Synthesis of pyrazinyl pyridine-3-sulfonamide compounds | ASTRAZENECA UK LIMITED (GB) | 2005-09-13 | — | — | US | disclosed |