Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 2/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 7/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL784140 | 0.76 | CA1 (0.51) | CA1CA2CA9CA12KDM4E | |
| SCHEMBL2565634 | 0.75 | CA2 (0.50) | CA1CA2CA9CA12KDM4E | |
| SCHEMBL10547969 | 0.72 | CA1 (0.57) | EDNRANOTUMCA1CA2CA9 | |
| SCHEMBL17694561 | 0.70 | NOTUM (0.78) | NOTUMTP53TLR8MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL29970039 | 0.68 | CA2 (0.53) | CA1CA2CA9CA12TP53 | |
| SCHEMBL2610163 | 0.68 | NOTUM (0.75) | NOTUMTP53TLR8MAPTKDM4E | |
| SCHEMBL29718566 | 0.66 | CA2 (0.47) | CA1CA2CA9CA12KDM4E | |
| SCHEMBL12474849 | 0.66 | CA1 (0.47) | CA1CA2CA9HPGDNPC1 | |
| SCHEMBL28216449 | 0.66 | CA2 (0.47) | CA1CA2CA9CA12HPGD | |
| SCHEMBL28975848 | 0.65 | NOTUM (0.56) | NOTUMTLR8KDM4ELMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120177705-A1 | COMPOSITION 064 | ASTRAZENECA AB (SE) | 2012-07-12 | — | — | US | disclosed |
| US-20120177705-A1 | COMPOSITION 064 | ASTRAZENECA AB (SE) | 2012-07-12 | — | — | US | disclosed |
| US-8168221-B2 | Composition 064 | ASTRAZENECA AB (SE) | 2012-05-01 | — | — | US | disclosed |
| US-8168221-B2 | Composition 064 | ASTRAZENECA AB (SE) | 2012-05-01 | — | — | US | disclosed |
| EP-2433620-A1 | Zibotentan Composition | AstraZeneca AB (SE) | 2012-03-28 | — | — | EP | disclosed |
| US-20090099203-A1 | COMPOSITION 064 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| US-20090099203-A1 | COMPOSITION 064 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| WO-2009047565-A2 | COMPOSITION 064 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099203-A1 | COMPOSITION 064 | MGAM, MAST4, MANBA | EDNRA 2957/4885NOTUM 1232/4885CA1 2352/4885 |
| US-20120177705-A1 | COMPOSITION 064 | MGAM, MAST4, MANBA | EDNRA 2957/4885NOTUM 1232/4885CA1 2352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.