SCHEMBL2565902

SCHEMBL2565902

[c]1nnccc1-c1ccco1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.42
KDM4E B2RXH2 8/20 0.42
HSD17B10 Q99714 5/20 0.42
HPGD P15428 5/20 0.42
POLB P06746 4/20 0.42
MAPT P10636 4/20 0.42
NPC1 O15118 4/20 0.42
RAB9A P51151 4/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
PKM P14618 3/20 0.42
TDP1 Q9NUW8 3/20 0.42
BLM P54132 3/20 0.42
ALOX15 P16050 2/20 0.42
CASP1 P29466 2/20 0.42
PTPN7 P35236 2/20 0.42
RECQL P46063 2/20 0.42
CASP7 P55210 2/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
USP2 O75604 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL450165 0.74 ALDH1A1 (0.43) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL452077 0.69 ALDH1A1 (0.42) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL5698280 0.67
SCHEMBL8183045 0.67 ALDH1A1 (0.43) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL978864 0.65 ALDH1A1 (0.42) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL1799678 0.65 ALDH1A1 (0.63) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL1036366 0.64 ALDH1A1 (0.45) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL1230266 0.63 RAB9A (0.48) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL297554 0.63 ALDH1A1 (0.43) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL22640 0.63 ALDH1A1 (0.43) ALDH1A1KDM4EHSD17B10HPGDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1399416-B1 PEPTIDE DEFORMYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2011-11-02 EP disclosed
EP-1115687-B1 5,6-DIHYDRONAPHTHALENYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2004-05-26 EP disclosed
EP-1115687-A4 5,6-DIHYDRONAPHTHALENYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2002-06-05 EP disclosed
EP-1115687-A1 5,6-DIHYDRONAPHTHALENYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2001-07-18 EP disclosed
US-6194601-B1 USEFUL IN TREATMENT OF SKIN DISORDERS SUCH AS ACNE AND DAMAGE FROM AGE OR IRRADIATION; CHRONIC SKIN INFLAMMATORY INFLAMMATORY DISEASES SUCH AS PSORIASIS AND ATOPIC DERMATITIS; ANTITUMOR AGENTS FOR BREAST CANCER, LUNG CANCER; NONTOXIC BRISTOL-MYERS SQUIBB COMPANY 2001-02-27 US disclosed
WO-2000017147-A1 5,6-DIHYDRONAPHTHALENYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2000-03-30 WO disclosed