Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | BLM | P54132 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69346 | 0.68 | ALDH1A1 (0.35) | ALDH1A1MEN1KMT2ATDP1ALOX15 | |
| SCHEMBL5260742 | 0.68 | PTK2 (0.39) | MEN1KMT2APKMLMNAGAA | |
| SCHEMBL450165 | 0.68 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL8062583 | 0.68 | NOTUM (0.38) | ALDH1A1KDM4ENPC1RAB9AGAA | |
| SCHEMBL2565902 | 0.67 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL978864 | 0.67 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL1799678 | 0.67 | ALDH1A1 (0.63) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL4947004 | 0.64 | KDM4E (0.39) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL1190969 | 0.64 | HPGDS (0.33) | — | |
| SCHEMBL4587267 | 0.64 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679297-B | LXR and FXR modulators | EXELIXIS INC | 2012-01-11 | — | — | CN | claimed |
| CN-101693695-A | Pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC | 2010-04-14 | — | — | CN | claimed |
| CN-1976905-A | Pyrimidine derivatives and methods of treatment related to their use | TAISHO PHARMACEUTICAL CO LTD (JP) | 2007-06-06 | — | — | CN | claimed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | claimed |
| CN-1582281-A | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO LTD (JP) | 2005-02-16 | — | — | CN | claimed |
| US-6080763-A | INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES, E.G., TUMOR NECROSIS FACTOR AND INTERLEUKIN-1; USEFUL TO TREAT CHRONIC INFLAMMATORY DISEASE; AUTOIMMUNE DISEASES, E.G. RHEUMATOID ARTHRITIS, OSTEOPOROSIS; PYRAZOLYLUREAS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-06-27 | — | — | US | claimed |
| US-20150297581-A1 | RHO KINASE INHIBITORS | ALCON INC. (CH) | 2015-10-22 | — | — | US | disclosed |
| CN-102883718-A | Analogues for the treatment or prevention of flavivirus infections | VERTEX PHARMA | 2013-01-16 | — | — | CN | disclosed |
| CN-102869657-A | Analogues for the treatment or prevention of flavivirus infections | VERTEX PHARMA | 2013-01-09 | — | — | CN | disclosed |
| CN-101868458-B | Isoxazolo-pyridazine derivatives | HOFFMANN LA ROCHE | 2012-11-28 | — | — | CN | disclosed |
| CN-101903342-B | Substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides and their therapeutic use as histamine H3 receptor modulators | SANOFI AVENTIS | 2012-11-21 | — | — | CN | disclosed |
| CN-1791395-B | Immunosuppressant compounds and compositions | IRM LLC | 2012-09-26 | — | — | CN | disclosed |
| CN-102625808-A | Spirocyclic amide derivatives | ASTRAZENECA AB | 2012-08-01 | — | — | CN | disclosed |
| CN-1729185-A | Nobel compounds having selective inhibiting effect at GSK3 | ASTRAZENECA AB (SE) | 2006-02-01 | — | — | CN | disclosed |
| CN-1726210-A | Novel compounds having selective inhibiting effect at GSK3 | ASTRAZENECA AB (SE) | 2006-01-25 | — | — | CN | disclosed |
| CN-1691944-A | Oxadiazoles as modulators of metabotropic glutamate receptor-5 | ASTRAZENECA AB (SE) | 2005-11-02 | — | — | CN | disclosed |
| CN-1642938-A | Novel compounds | ASTRAZENECA AB (SE) | 2005-07-20 | — | — | CN | disclosed |
| CN-1582281-A | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO LTD (JP) | 2005-02-16 | — | — | CN | disclosed |
| CN-1333767-A | Aromatic heterocyclic compounds as antiinflammatory agent | BOEHRINGER INGELHELM PHARMACEU (US) | 2002-01-30 | — | — | CN | disclosed |
| CN-1153779-A | 2-(4-pyrazoloxy-pyrimidin-5-yl) acetic acid derivatives | SANDOZ LTD (CH) | 1997-07-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150297581-A1 | RHO KINASE INHIBITORS | ROCK1, ROCK2, CIT | ALDH1A1 4263/4885KDM4E 2089/4885HPGD 630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.