Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | BLM | P54132 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1799678 | 0.71 | ALDH1A1 (0.63) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL297554 | 0.68 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL25757 | 0.67 | — | — | |
| SCHEMBL549043 | 0.65 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL630904 | 0.65 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL4810005 | 0.65 | MAOB (0.46) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL15987379 | 0.64 | ALDH1A1 (0.39) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL450165 | 0.64 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL8183045 | 0.64 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL4947004 | 0.64 | KDM4E (0.39) | ALDH1A1KDM4EHPGDMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 247 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2781512-B1 | OXADIAZOLE COMPOUND AND PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | UNIV SHANGHAI JIAOTONG (CN) | 2017-06-28 | — | — | EP | claimed |
| US-8916554-B2 | Amino-derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2014-12-23 | — | — | US | claimed |
| US-8318774-B2 | N-(3-((thiazol-2-yl)amino)propyl)-3-phenylpropiolamide, 4-(thiazol-2-yl-amino)-1-(3-phenyl-propiolyl)piperidine, for example; for preventing or treating a disorder or disease that is mediated at least in part by mGluR26 receptors, such as pain, migraines, depression, neurodegenerative diseases | GRUENENTHAL GMBH (DE) | 2012-11-27 | — | — | US | claimed |
| EP-2007729-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE LABOR DR (ES) | 2012-06-27 | — | — | EP | claimed |
| EP-2427435-A1 | SUBSTITUTED PHENYLUREAS AND PHENYLAMIDES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2012-03-14 | — | — | EP | claimed |
| US-8044053-B2 | Sulfonamide substituted pyrazoline compounds, their preparation and use as CB1 modulators | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2011-10-25 | — | — | US | claimed |
| EP-1851210-B1 | NITRO-SUBSTITUTED PHENYL-PIPERAZINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE LABOR DR (ES) | 2011-10-19 | — | — | EP | claimed |
| EP-1968963-B1 | SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING ANALGESICS | GRUENENTHAL GMBH (DE) | 2011-10-05 | — | — | EP | claimed |
| WO-2011109441-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2011-09-09 | — | — | WO | claimed |
| US-8008304-B2 | [1] 1-(3-phenyl-propiolyl)-4-(thiophen-3-yl)-piperazine; pain treatments; mGluR5 receptor regulation | Grüenthal GmbH (DE) | 2011-08-30 | — | — | US | claimed |
| US-20070015784-A1 | Subsitituted 1,4,8- triazaspiro [4,5]decan-2-one compounds | GRUENENTHAL GMBH (DE) | 2007-01-18 | — | — | US | claimed |
| EP-1717227-A1 | Substituted indole compounds, their preparation and use in medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-11-02 | — | — | EP | claimed |
| US-20060036101-A1 | Substituted indole compounds, their preparation and use in medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2006-02-16 | — | — | US | claimed |
| WO-2006015867-A1 | SUBSTITUTED INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-02-16 | — | — | WO | claimed |
| WO-2005105798-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND DRUGS CONTAINING SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |
| US-6777441-B2 | FOR THERAPY AND PROPHYLAXIS | EMORY UNIVERSITY | 2004-08-17 | — | — | US | claimed |
| EP-1355907-A1 | THIAZOLYL-, OXAZOLYL-, PYRROLYL-, AND IMIDAZOLYL-ACID AMIDE DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | Pfizer Products Inc. (US) | 2003-10-29 | — | — | EP | claimed |
| EP-1355884-A1 | NICOTINAMIDE BIARYL DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | Pfizer Products Inc. (US) | 2003-10-29 | — | — | EP | claimed |
| WO-2002060898-A1 | THIAZOLYL-, OXAZOLYL-, PYRROLYL-, AND IMIDAZOLYL-ACID AMIDE DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER PRODUCTS INC. (US) | 2002-08-08 | — | — | WO | claimed |
| WO-2002060875-A1 | NICOTINAMIDE BIARYL DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER PRODUCTS INC. (US) | 2002-08-08 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060036101-A1 | Substituted indole compounds, their preparation and use in medicaments | HTR6, TPH1, TPH2 | ALDH1A1 990/4885KDM4E 2527/4885HPGD 573/4885 |
| US-20070015784-A1 | Subsitituted 1,4,8- triazaspiro [4,5]decan-2-one compounds | SI, SSTR4, SLC10A2 | ALDH1A1 2780/4885KDM4E 3667/4885HPGD 2897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.