Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 14/20 | 0.57 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.48 |
| ▸ | KCNJ8 | Q15842 | 5/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29881583 | 0.75 | NAMPT (0.81) | NAMPT | |
| SCHEMBL20379763 | 0.75 | NAMPT (0.81) | NAMPT | |
| SCHEMBL164510 | 0.73 | NAMPT (1.00) | NAMPT | |
| SCHEMBL20380098 | 0.73 | NAMPT (0.76) | NAMPT | |
| SCHEMBL29881557 | 0.73 | NAMPT (0.76) | NAMPT | |
| SCHEMBL20389102 | 0.72 | NAMPT (0.78) | NAMPT | |
| SCHEMBL27955163 | 0.71 | ABCC9 (0.54) | NAMPTABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL21132840 | 0.68 | NAMPT (0.55) | NAMPT | |
| SCHEMBL22954102 | 0.67 | HTR6 (0.61) | NAMPTABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL21132533 | 0.66 | NAMPT (0.55) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012031196-A1 | 4- { [ ( PYRIDIN- 3 - YL -METHYL) AMINOCARBONYL] AMINO} BENZENE - SULFONE DERIVATIVES AS NAMPT INHIBITORS FOR THERAPY OF DISEASES SUCH AS CANCER | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |