Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 7/20 | 0.54 |
| ▸ | ABCC8 | Q09428 | 7/20 | 0.54 |
| ▸ | KCNJ11 | Q14654 | 7/20 | 0.54 |
| ▸ | KCNJ8 | Q15842 | 7/20 | 0.54 |
| ▸ | NAMPT | P43490 | 3/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22954102 | 0.83 | HTR6 (0.61) | ABCC9ABCC8KCNJ11KCNJ8NAMPT | |
| SCHEMBL13728197 | 0.77 | NAMPT (0.49) | ABCC9ABCC8KCNJ11KCNJ8NAMPT | |
| SCHEMBL13728179 | 0.77 | NAMPT (0.48) | ABCC9ABCC8KCNJ11KCNJ8NAMPT | |
| SCHEMBL10154346 | 0.75 | ALPL (0.52) | CNR2HTR6SLC22A12ALPLCYP1A2 | |
| SCHEMBL28835290 | 0.73 | ABCC9 (0.56) | ABCC9ABCC8KCNJ11KCNJ8NAMPT | |
| SCHEMBL27941960 | 0.73 | ABCC9 (0.54) | ABCC9ABCC8KCNJ11KCNJ8NAMPT | |
| SCHEMBL2646108 | 0.73 | ALPL (0.46) | CNR2HTR6SLC22A12ALPL | |
| SCHEMBL6972429 | 0.71 | ALPL (0.47) | CNR2HTR6SLC22A12ALPL | |
| SCHEMBL3528957 | 0.71 | ELANE (0.60) | CNR2HTR6SLC22A12ALPL | |
| SCHEMBL6735794 | 0.71 | ALPL (0.51) | HTR6SLC22A12ALPLMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717574-B | Novel compounds and compositions for the inhibition of nampt | 福马TM有限责任公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-103717574-A | Novel compounds and compositions for the inhibition of nampt | FORMA TM LLC | 2014-04-09 | — | — | CN | disclosed |