Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.58 |
| ▸ | HTR1A | P08908 | 4/20 | 0.58 |
| ▸ | DRD3 | P35462 | 4/20 | 0.58 |
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | DRD1 | P21728 | 2/20 | 0.58 |
| ▸ | DRD5 | P21918 | 2/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8571166 | 0.95 | DRD2 (0.59) | DRD2HTR1ADRD3HTR2ADRD1 | |
| SCHEMBL8011291 | 0.92 | DRD2 (0.65) | DRD2HTR1ADRD3HTR2ADRD1 | |
| SCHEMBL8001978 | 0.90 | DRD2 (0.63) | DRD2HTR1ADRD3HTR2ADRD1 | |
| SCHEMBL8207578 | 0.89 | DRD2 (0.73) | DRD2HTR1ADRD3HTR2ADRD1 | |
| SCHEMBL8001944 | 0.89 | DRD2 (0.65) | DRD2HTR1ADRD3HTR2ADRD1 | |
| SCHEMBL8012789 | 0.85 | DRD2 (0.60) | DRD2HTR1ADRD3HTR2ADRD1 | |
| SCHEMBL9970928 | 0.84 | DRD2 (0.58) | DRD2HTR1ADRD3DRD1DRD5 | |
| SCHEMBL256658 | 0.84 | DRD2 (0.82) | DRD2HTR1ADRD3HTR2ADRD1 | |
| SCHEMBL256656 | 0.84 | DRD2 (0.78) | DRD2HTR1ADRD3DRD1DRD5 | |
| SCHEMBL29048468 | 0.83 | SIGMAR1 (0.68) | DRD2HTR1ADRD3HTR2ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028578-A1 | SUBSTITUTED FUSED PYRIMIDINONES AND DIHYDROPYRIMIDINONES | BAYER CROPSCIENCE AG (DE) | 2012-03-08 | — | — | WO | disclosed |
| US-5837707-A | USEFUL IN TREATING ANXIETY, PSYCHOSIS, EPILEPSY, CONVULSIONS, AMNESIA, PARKINSON'S DISEASE | H. LUNDBECK A/S (DK) | 1998-11-17 | — | — | US | disclosed |
| US-5830896-A | PSYCHOLOGICAL DISORDERS; ANTIEPILEPIC AGENTS; ALZHEIMER'SAND PARKINSON?S DISEASE | H. LUNDBECK A/S (DK) | 1998-11-03 | — | — | US | disclosed |
| US-5684012-A | TREATMENT OF PSYCHOLOGICAL AND NEUROLOGICAL DISORDERS | H. LUNDBECK A/S (DK) | 1997-11-04 | — | — | US | disclosed |