Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CAD | P27708 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL712601 | 0.85 | SMN1; SMN2 (0.33) | ALDH1A1CYP2C19PLA2G2ALMNACA12 | |
| SCHEMBL12903917 | 0.81 | CYP2D6 (0.44) | ALDH1A1CYP3A4ALOX15CYP2D6CYP2C9 | |
| SCHEMBL13799012 | 0.80 | PLA2G2A (0.37) | ALDH1A1CYP2C19TSHRPLA2G2ALMNA | |
| SCHEMBL5877427 | 0.79 | CYP1A2 (0.50) | ALDH1A1CYP2D6CYP2C9CYP2C19GAA | |
| SCHEMBL4860398 | 0.79 | LMNA (0.34) | ALDH1A1CYP2C19PLA2G2ALMNACA12 | |
| SCHEMBL9304618 | 0.79 | CYP3A4 (0.41) | ALDH1A1CYP3A4CYP2C9CYP2C19PLA2G2A | |
| SCHEMBL5231692 | 0.77 | KDM4E (0.36) | ALDH1A1ALOX15CYP2C19TDP1PLA2G2A | |
| SCHEMBL14601302 | 0.72 | ALDH1A1 (0.46) | ALDH1A1ALOX15CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8837118 | 0.72 | ALDH1A1 (0.46) | ALDH1A1ALOX15CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4421264 | 0.71 | ALDH1A1 (0.43) | ALDH1A1CYP3A4ALOX15CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183180-A1 | PROCESS OF MAKING ROXADUSTAT | SUZHOU PENGXU PHARMATECH CO., LTD. (CN) | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183180-A1 | PROCESS OF MAKING ROXADUSTAT | CYP2B6, UGT1A6, CYP2D6 | ALDH1A1 752/4885CYP3A4 15/4885ALOX15 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.