Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.55 |
| ▸ | AHR | P35869 | 3/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | BCR | P11274 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12047534 | 1.00 | KDM4E (0.59) | KDM4ECYP3A4LMNATP53TSHR | |
| SCHEMBL8647769 | 1.00 | KDM4E (0.59) | KDM4ECYP3A4LMNATP53TSHR | |
| SCHEMBL13778032 | 0.94 | KDM4E (0.53) | KDM4ECYP3A4LMNATP53TSHR | |
| SCHEMBL9954760 | 0.90 | NFE2L2 (0.55) | KDM4ECYP3A4LMNATP53TSHR | |
| SCHEMBL9954764 | 0.90 | NFE2L2 (0.55) | KDM4ECYP3A4LMNATP53TSHR | |
| SCHEMBL9954765 | 0.90 | NFE2L2 (0.55) | KDM4ECYP3A4LMNATP53TSHR | |
| SCHEMBL9960769 | 0.90 | NFE2L2 (0.55) | KDM4ECYP3A4LMNATP53TSHR | |
| SCHEMBL22252716 | 0.86 | KDM4E (0.53) | KDM4ECYP3A4LMNATP53TSHR | |
| SCHEMBL31336548 | 0.85 | KDM4E (0.48) | KDM4ECYP3A4LMNATP53TSHR | |
| SCHEMBL31336333 | 0.85 | KDM4E (0.48) | KDM4ECYP3A4LMNATP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11739074-B2 | Ras inhibitors | Revolution Medicines, Inc. (US) | 2023-08-29 | — | — | US | disclosed |
| US-20230233569-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2023-07-27 | — | — | US | disclosed |
| CN-112266352-B | Piperlongumine derivative and preparation method and application thereof | 绍兴文理学院 | 2022-02-08 | — | — | CN | disclosed |
| US-20210179648-A1 | P2X3 AND/OR P2X2/3 RECEPTOR ANTAGONIST, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF | BEIJING TIDE PHARMACEUTICAL CO., LTD. (CN) | 2021-06-17 | — | — | US | disclosed |
| US-10934531-B2 | Method for enantioselective carbene C—H insertion using an iron-containing protein catalyst | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2021-03-02 | — | — | US | disclosed |
| US-10934531-B2 | Method for enantioselective carbene C—H insertion using an iron-containing protein catalyst | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2021-03-02 | — | — | US | disclosed |
| CN-108383694-B | Preparation method of cyclobutane derivative | 华中科技大学 | 2020-09-18 | — | — | CN | disclosed |
| CN-110878001-A | Process for the isomerization of (Z) -olefins to (E) -olefins | 温州大学 | 2020-03-13 | — | — | CN | disclosed |
| US-20190276805-A1 | METHOD FOR ENANTIOSELECTIVE CARBENE C-H INSERTION USING AN IRON-CONTAINING PROTEIN CATALYST | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2019-09-12 | — | — | US | disclosed |
| US-20190276805-A1 | METHOD FOR ENANTIOSELECTIVE CARBENE C-H INSERTION USING AN IRON-CONTAINING PROTEIN CATALYST | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2019-09-12 | — | — | US | disclosed |
| US-20120009615-A1 | DIPYRROMETHENE-BORON HYDROPHILIC FLUORESCENT COMPOUNDS | UNIVERSITE DE STRASBOURG (50% PART INTEREST) (FR) | 2012-01-12 | — | — | US | disclosed |
| US-20110281862-A1 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA (IT) | 2011-11-17 | — | — | US | disclosed |
| EP-2055746-A2 | Colored curable composition, color filter, method of producing the same, and solid state image pickup device. | Fujifilm Corporation (JP) | 2009-05-06 | — | — | EP | disclosed |
| US-20070244160-A1 | 6-11 Bicyclic Ketolide Derivatives | OR YAT SUN | 2007-10-18 | — | — | US | disclosed |
| US-7169786-B2 | Isoxazoline derivatives as anti-depressants | JANSSEN-CILAG S.A. (ES) | 2007-01-30 | — | — | US | disclosed |
| US-7169786-B2 | Isoxazoline derivatives as anti-depressants | JANSSEN-CILAG S.A. (ES) | 2007-01-30 | — | — | US | disclosed |
| US-5466838-A | Catalytic reaction of olefin with oxygen in the presence of aldehyde | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1995-11-14 | — | — | US | disclosed |
| EP-0540009-B1 | Process for producing epoxides | SUMITOMO CHEMICAL CO (JP) | 1995-08-30 | — | — | EP | disclosed |
| US-5367087-A | Process for producing epoxide | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1994-11-22 | — | — | US | disclosed |
| EP-0540009-A1 | Process for producing epoxides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-05-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179648-A1 | P2X3 AND/OR P2X2/3 RECEPTOR ANTAGONIST, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF | P2RX3, P2RX2, P2RX7 | KDM4E 4725/4885CYP3A4 2252/4885LMNA 1680/4885 |
| US-11739074-B2 | Ras inhibitors | KRAS, NRAS, HRAS | KDM4E 3344/4885CYP3A4 3310/4885LMNA 3858/4885 |
| US-20070244160-A1 | 6-11 Bicyclic Ketolide Derivatives | AKR1C2, AKR1C3, AKR1C1 | KDM4E 56/4885CYP3A4 24/4885LMNA 4270/4885 |
| US-20110281862-A1 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | ALK, BCR, NPM1 | KDM4E 2789/4885CYP3A4 3175/4885LMNA 1863/4885 |
| US-20120009615-A1 | DIPYRROMETHENE-BORON HYDROPHILIC FLUORESCENT COMPOUNDS | LDHB, AHR, BCR | KDM4E 4804/4885CYP3A4 2316/4885LMNA 94/4885 |
| US-20230233569-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | KRAS, HRAS, MTOR | KDM4E 2157/4885CYP3A4 4873/4885LMNA 1680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.