SCHEMBL25679151

SCHEMBL25679151

c1ccc(C(c2ccccc2)N2CCn3c(nnc3-c3cncnc3)C2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.40
CHRM4 P08173 1/20 0.40
CHRM5 P08912 1/20 0.40
ADRA2A P08913 1/20 0.40
ADORA3 P0DMS8 1/20 0.40
CYP2D6 P10635 1/20 0.40
CHRM1 P11229 1/20 0.40
CHRM3 P20309 1/20 0.40
DRD1 P21728 1/20 0.40
ADRA1D P25100 1/20 0.40
HTR2A P28223 1/20 0.40
HTR2C P28335 1/20 0.40
HRH1 P35367 1/20 0.40
OPRM1 P35372 1/20 0.40
DRD3 P35462 1/20 0.40
HTR2B P41595 1/20 0.40
SLC6A3 Q01959 1/20 0.40
KCNH2 Q12809 1/20 0.40
P2RX7 Q99572 2/20 0.39
HPGD P15428 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25680084 0.93 OPRD1 (0.46) OPRM1P2RX7ALDH1A1OPRD1MGLL
SCHEMBL25679011 0.89 HPGD (0.50) CHRM2CHRM4CHRM5ADRA2AADORA3
SCHEMBL25679010 0.86 HPGD (0.42) CHRM2CHRM4CHRM5ADRA2AADORA3
SCHEMBL25679957 0.86 OPRD1 (0.47) OPRM1P2RX7ALDH1A1OPRD1KMT2A
SCHEMBL25676368 0.86 DPP4 (0.43) CHRM2CHRM4CHRM5ADRA2AADORA3
SCHEMBL25680562 0.86 ALDH1A1 (0.39) CHRM2CHRM4CHRM5ADRA2AADORA3
SCHEMBL25679306 0.85 P2RX7 (0.39) CHRM2CHRM4CHRM5ADRA2AADORA3
SCHEMBL25679008 0.85 ALDH1A1 (0.39) CHRM2CHRM4CHRM5ADRA2AADORA3
SCHEMBL25679304 0.85 EGFR (0.39) CHRM2ADRA2AADORA3CYP2D6CHRM1
SCHEMBL25679855 0.83 P2RX7 (0.49) CYP2D6OPRM1DRD3P2RX7HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023122260-A2 INHIBITORS OF SARS-COV-2 THE TEXAS A&M UNIVERSITY SYSTEM (US) 2023-06-29 WO disclosed