Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | ATP4A | P20648 | 1/20 | 0.38 |
| ▸ | ATP4B | P51164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8194463 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDKCNH2HTT | |
| SCHEMBL25679799 | 0.85 | CALM1 (0.44) | ALDH1A1ADORA2AADORA1HTTL3MBTL1 | |
| SCHEMBL9356136 | 0.81 | KCNH2 (0.47) | ALDH1A1KDM4EHPGDKCNH2L3MBTL1 | |
| SCHEMBL25679800 | 0.81 | TSHR (0.50) | ALDH1A1KDM4EADORA2AADORA1HTT | |
| SCHEMBL25928587 | 0.77 | HPGD (0.41) | HPGDKCNH2TDP1 | |
| SCHEMBL24156678 | 0.76 | RAB9A (0.46) | HPGDHTTL3MBTL1NOS2 | |
| SCHEMBL29222897 | 0.76 | KCNH2 (0.53) | ALDH1A1KDM4EHPGDKCNH2TDP1 | |
| SCHEMBL25946165 | 0.75 | HPGD (0.42) | ALDH1A1KDM4EHPGDKCNH2L3MBTL1 | |
| SCHEMBL26608275 | 0.73 | MAOB (0.50) | ALDH1A1HTTL3MBTL1 | |
| SCHEMBL568443 | 0.72 | ACHE (0.36) | ALDH1A1KDM4EADORA2AADORA1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023114200-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS AND INTERMEDIATES THEREOF | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023114198-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |