Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PPP5C | P53041 | 2/20 | 0.47 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.47 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.47 |
| ▸ | NPY4R | P50391 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.42 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539777 | 0.94 | HTT (0.59) | HTTLMNAALDH1A1TSHRPPP5C | |
| SCHEMBL8194135 | 0.88 | HTT (0.71) | HTTLMNAALDH1A1TSHRPPP5C | |
| SCHEMBL2075903 | 0.86 | HTT (0.81) | HTTLMNAALDH1A1TSHRPPP5C | |
| SCHEMBL13779943 | 0.85 | CYP1A2 (0.65) | HTTLMNAALDH1A1TSHRPPP5C | |
| SCHEMBL2049321 | 0.83 | ALDH1A1 (0.62) | HTTLMNAALDH1A1TSHRHPGD | |
| SCHEMBL484763 | 0.83 | HTT (0.53) | HTTLMNAALDH1A1TSHRPPP5C | |
| SCHEMBL16002978 | 0.82 | HTT (0.55) | HTTLMNAALDH1A1TSHRPPP5C | |
| SCHEMBL493733 | 0.82 | HPGD (0.61) | HTTLMNAALDH1A1TSHRTFPI2 | |
| SCHEMBL12632672 | 0.82 | LMNA (0.79) | HTTLMNAALDH1A1TSHRPPP5C | |
| SCHEMBL4135869 | 0.82 | LMNA (0.85) | HTTLMNAALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102325780-B | 6-phenyl-2-[((piperidin-4-ylmethyl)-piperazin-1yl) or piperazin 1-ylmethyl)-piperidin-1-yl)]-imidazo[2,1-b][1,3,4]thiadiazole derivatives and their use | URIFER LTD | 2014-12-03 | — | — | CN | disclosed |
| EP-2066659-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2013-08-28 | — | — | EP | disclosed |
| CN-101528681-B | New sulfonamide derivatives as bradykinin antagonists | RITCHER GEDEON NYRT | 2013-01-30 | — | — | CN | disclosed |
| CN-102325780-A | 6-phenyl-2-[((piperidin-4-yl-methyl)-piperazine-1-yl) be ((piperazine-1-base-methyl)-piperidines-1-yl) perhaps]-imidazoles-[2,1-b] [1,3,4] thiadiazoles derivative and application thereof | URIFER LTD | 2012-01-18 | — | — | CN | disclosed |
| EP-2383267-A1 | Substituted sulfonamide derivatives | Grünenthal GmbH (DE) | 2011-11-02 | — | — | EP | disclosed |
| CN-101528681-A | New sulfonamide derivatives as bradykinin antagonists | RITCHER GEDEON NYRT (HU) | 2009-09-09 | — | — | CN | disclosed |
| EP-2066659-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008040492-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-04-10 | — | — | WO | disclosed |