Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PPP5C | P53041 | 2/20 | 0.41 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.41 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.41 |
| ▸ | NPY4R | P50391 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14996485 | 0.90 | HTT (0.59) | HTTLMNAITGB3ITGA2BALDH1A1 | |
| SCHEMBL2818946 | 0.85 | HPGD (0.55) | HTTLMNAITGB3ITGA2BALDH1A1 | |
| SCHEMBL2569643 | 0.83 | HTT (0.62) | HTTLMNAALDH1A1TSHRPPP5C | |
| SCHEMBL14996487 | 0.82 | HTT (0.57) | HTTLMNAITGB3ITGA2BALDH1A1 | |
| SCHEMBL13168273 | 0.82 | HSD11B1 (0.56) | HTTLMNAITGB3ITGA2BALDH1A1 | |
| SCHEMBL13131050 | 0.82 | HTT (0.50) | HTTLMNAITGB3ITGA2BALDH1A1 | |
| SCHEMBL4539777 | 0.81 | HTT (0.59) | HTTLMNAALDH1A1TSHRPPP5C | |
| SCHEMBL13131241 | 0.81 | HTT (0.53) | HTTLMNAITGB3ITGA2BALDH1A1 | |
| SCHEMBL25499364 | 0.81 | HTT (0.45) | HTTLMNAITGB3ITGA2BALDH1A1 | |
| SCHEMBL2816787 | 0.80 | HPGD (0.57) | HTTLMNAITGB3ITGA2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| EP-2411381-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-02-01 | — | — | EP | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
| WO-2010108651-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | HTT 3621/4885LMNA 1187/4885ITGB3 3292/4885 |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | HTT 3621/4885LMNA 1187/4885ITGB3 3292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.