Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12077838 | 0.84 | MAPT (0.73) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10784693 | 0.80 | PSEN1 (0.53) | MAPTSMN1; SMN2TDP1VCAM1NPSR1 | |
| SCHEMBL671244 | 0.77 | SMN1; SMN2 (0.69) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4066329 | 0.77 | SIGMAR1 (0.61) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6700039 | 0.77 | ALDH1A1 (0.60) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17645850 | 0.76 | MAPT (1.00) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4062112 | 0.75 | MAPT (0.78) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12169294 | 0.74 | LMNA (0.52) | MAPTMEN1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL3258566 | 0.74 | MAPT (0.54) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13508573 | 0.74 | CNR2 (0.50) | MAPTSMN1; SMN2TDP1VCAM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382215-A1 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010076525-A1 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-07-08 | — | — | WO | disclosed |