Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13563553 | 0.95 | TRPA1 (0.44) | NOS3NOS1NOS2POLBGBA1 | |
| SCHEMBL20961845 | 0.77 | TRPA1 (0.46) | POLBTRPA1 | |
| SCHEMBL21439968 | 0.76 | KMT2A (0.49) | TRPA1 | |
| SCHEMBL16765854 | 0.75 | TRPA1 (0.42) | NOS3NOS1NOS2POLBGBA1 | |
| Hydrochloric Acid SCHEMBL1809435 | 0.74 | ARG1 (0.48) | NOS3NOS1NOS2 | |
| SCHEMBL5958283 | 0.73 | NOS3 (0.42) | NOS3NOS1NOS2POLBGBA1 | |
| SCHEMBL28922378 | 0.73 | TRPA1 (0.48) | NOS3NOS1NOS2POLBGBA1 | |
| SCHEMBL21216554 | 0.71 | NPSR1 (0.43) | — | |
| SCHEMBL12645999 | 0.71 | NOS3 (0.39) | NOS3NOS1NOS2POLBGBA1 | |
| SCHEMBL23459337 | 0.70 | POLB (0.51) | POLBGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11685734-B2 | ATM kinase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2023-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11685734-B2 | ATM kinase inhibitors and compositions and methods of use thereof | ATM, CHEK2, CHEK1 | NOS3 2860/4885NOS1 2814/4885NOS2 2951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.