Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2001093 | 0.84 | HCRTR1 (0.39) | MEN1HTTKMT2AL3MBTL1 | |
| SCHEMBL2568224 | 0.81 | HCRTR1 (0.39) | MEN1HTTKMT2AL3MBTL1GRM5 | |
| SCHEMBL2571779 | 0.80 | AGBL2 (0.42) | MEN1HTTKMT2AL3MBTL1GRM5 | |
| SCHEMBL15520466 | 0.71 | HCAR2 (0.39) | — | |
| SCHEMBL1284719 | 0.69 | MEN1 (0.39) | MEN1HTTKMT2AL3MBTL1 | |
| SCHEMBL2924337 | 0.69 | ALDH1A1 (0.49) | MEN1HTTKMT2AL3MBTL1 | |
| SCHEMBL5653393 | 0.69 | SMN1; SMN2 (0.43) | MEN1HTTKMT2AL3MBTL1 | |
| SCHEMBL2924565 | 0.69 | ALDH1A1 (0.39) | MEN1HTTKMT2AL3MBTL1 | |
| SCHEMBL21247482 | 0.68 | KMT2A (0.63) | MEN1HTTKMT2AL3MBTL1 | |
| SCHEMBL19921435 | 0.68 | CYP2C9 (0.49) | MEN1HTTKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945631-B1 | 4- (3-AMINOPYRAZOLE) PYRIMIDINE DERIVATIVES FOR USE AS TYROSINE KINASE INHIBITORS IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| EP-2383268-A1 | Pyrazolylaminopyridine derivatives useful as kinase inhibitors | AstraZeneca AB (SE) | 2011-11-02 | — | — | EP | disclosed |