SCHEMBL25699409

SCHEMBL25699409

CC(C)[SiH2]NC(=O)CN1C(=O)C=CC1=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3A P49840 1/20 0.42
GSK3B P49841 1/20 0.42
MGLL Q99685 4/20 0.36
ALDH1A1 P00352 3/20 0.36
BLM P54132 2/20 0.36
LMNA P02545 2/20 0.36
MAPT P10636 2/20 0.36
NPSR1 Q6W5P4 2/20 0.36
GMNN O75496 1/20 0.36
THPO P40225 1/20 0.36
PMP22 Q01453 1/20 0.36
KMT2A Q03164 3/20 0.36
MEN1 O00255 1/20 0.36
HPGD P15428 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C19 P33261 1/20 0.36
WRN Q14191 1/20 0.36
HIF1A Q16665 1/20 0.36
FAAH O00519 2/20 0.32
PTGS1 P23219 6/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL437306 0.77 GSK3A (0.50) GSK3AGSK3BMGLLALDH1A1BLM
SCHEMBL15386866 0.77 KMT2A (0.56) GSK3AGSK3BMGLLALDH1A1BLM
SCHEMBL19545832 0.74 GSK3A (0.47) GSK3AGSK3BMGLLALDH1A1BLM
SCHEMBL29995038 0.73 GSK3A (0.48) GSK3AGSK3BMGLLALDH1A1BLM
SCHEMBL30395097 0.72 GSK3A (0.42) GSK3AGSK3BMGLLALDH1A1BLM
SCHEMBL25704255 0.72 GSK3A (0.42) GSK3AGSK3BMGLLALDH1A1BLM
SCHEMBL20287639 0.71 GSK3A (0.44) GSK3AGSK3BMGLLALDH1A1BLM
SCHEMBL22281365 0.71 GSK3A (0.47) GSK3AGSK3BMGLLALDH1A1BLM
SCHEMBL20960449 0.71 KMT2A (0.41) GSK3AGSK3BMGLLALDH1A1BLM
SCHEMBL25680050 0.71 L3MBTL1 (0.49) LMNANPSR1KMT2AMEN1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023109942-A1 COMPOUND-LINKER CONSTRUCTS COMPRISING NOVEL COMPOUNDS USEFUL AS STING AGONISTS AND USES THEREOF JACOBIO PHARMACEUTICALS CO., LTD. (CN) 2023-06-22 WO disclosed