SCHEMBL257014

SCHEMBL257014

O=C(Cl)c1ncc(F)cc1F

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.39
DPP9 Q86TI2 1/20 0.39
AGBL2 Q5U5Z8 1/20 0.37
HCAR2 Q8TDS4 1/20 0.35
SPR P35270 1/20 0.35
CES2 O00748 2/20 0.33
CES1 P23141 2/20 0.33
KDM4E B2RXH2 1/20 0.33
ASPH Q12797 1/20 0.33
KDM8 Q8N371 1/20 0.33
ALDH1A1 P00352 1/20 0.33
ALOX15 P16050 1/20 0.33
KCNQ3 O43525 1/20 0.33
KCNQ2 O43526 1/20 0.33
KCNE1 P15382 1/20 0.33
KCNQ1 P51787 1/20 0.33
PDK2 Q15119 2/20 0.33
BACE1 P56817 2/20 0.33
GRM5 P41594 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31514824 1.00 DPP4 (0.39) DPP4DPP9AGBL2HCAR2SPR
SCHEMBL17668612 0.82 GLA (0.37) AGBL2HCAR2SPRALDH1A1ALOX15
SCHEMBL7687780 0.82 KCNQ3 (0.36) HCAR2SPRALDH1A1KCNQ3KCNQ2
SCHEMBL107357 0.81 HCAR2 (0.45) DPP4DPP9AGBL2HCAR2SPR
SCHEMBL22854245 0.80 AGBL2 (0.35) DPP4DPP9AGBL2HCAR2SPR
SCHEMBL17668865 0.80 AGBL2 (0.50) AGBL2HCAR2SPRKDM4EALDH1A1
SCHEMBL1661089 0.80 DGAT1 (0.35) HCAR2KDM4EASPHKDM8ALDH1A1
SCHEMBL30641925 0.79 DPP4 (0.39) DPP4DPP9AGBL2HCAR2BACE1
SCHEMBL18784193 0.79 AGBL2 (0.37) DPP4DPP9AGBL2HCAR2SPR
SCHEMBL1395991 0.79 AGBL2 (0.41) DPP4DPP9AGBL2HCAR2SPR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025093631-A1 A PROCESS FOR PREPARING 2-AMINO-3,5-DIFLUOROPYRIDINE OR A SALT THEREOF INTERVET INTERNATIONAL B.V. (NL) 2025-05-08 WO claimed
EP-4658074-A1 FUNGICIDAL COMPOSITIONS Syngenta Crop Protection AG (CH) 2025-12-10 EP disclosed
EP-4655284-A1 MICROBIOCIDAL PYRAZOLE DERIVATIVES Syngenta Crop Protection AG (CH) 2025-12-03 EP disclosed
WO-2025242908-A2 NOVEL COMPOUNDS GENOME THERAPEUTICS LTD (GB) 2025-11-27 WO disclosed
EP-4626232-A1 FUNGICIDAL COMPOSITIONS Syngenta Crop Protection AG (CH) 2025-10-08 EP disclosed
EP-4619396-A1 MICROBIOCIDAL TETRAHYDROISOQUINOLINE DERIVATIVES Syngenta Crop Protection AG (CH) 2025-09-24 EP disclosed
WO-2025133338-A1 QUINOLONE DERIVATVES AGAINST CANCER GENOME THERAPEUTICS LTD (GB) 2025-06-26 WO disclosed
WO-2025093631-A1 A PROCESS FOR PREPARING 2-AMINO-3,5-DIFLUOROPYRIDINE OR A SALT THEREOF INTERVET INTERNATIONAL B.V. (NL) 2025-05-08 WO disclosed
WO-2024160801-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2024-08-08 WO disclosed
WO-2024156886-A1 MICROBIOCIDAL PYRAZOLE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2024-08-02 WO disclosed
US-20130210824-A1 Substituted fused imidazoles and pyrazoles and use thereof BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-08-15 US disclosed
US-20130210824-A1 Substituted fused imidazoles and pyrazoles and use thereof BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-08-15 US disclosed
WO-2013104598-A2 SUBSTITUTED, ANNULATED IMIDAZOLES AND PYRAZOLES, AND USE THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-07-18 WO disclosed
WO-2012059548-A1 BENZYL-SUBSTITUTED CARBAMATES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-05-10 WO disclosed
WO-2012059549-A1 SUBSTITUTED 6-FLUORO-1H-PYRAZOLO[4,3-B]PYRIDINES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-05-10 WO disclosed
WO-2012028647-A1 BICYCLIC AZA HETEROCYCLES, AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-03-08 WO disclosed
EP-2406230-A1 SUBSTITUTED INDAZOLE AMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS Pfizer Inc. (US) 2012-01-18 EP disclosed
US-20110319379-A1 Substituted Indazole Amides And Their Use As Glucokinase Activators CORBETT JEFFREY W (US) 2011-12-29 US disclosed
WO-2011158149-A1 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES PFIZER INC. (US) 2011-12-22 WO disclosed
WO-2010103438-A1 SUBSTITUTED INDAZOLE AMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS PFIZER INC. (US) 2010-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130210824-A1 Substituted fused imidazoles and pyrazoles and use thereof CYP4F3, CYP11B2, CYP4F2 DPP4 91/4885DPP9 155/4885AGBL2 4310/4885
US-20110319379-A1 Substituted Indazole Amides And Their Use As Glucokinase Activators GCKR, GCK, GALK1 DPP4 267/4885DPP9 307/4885AGBL2 3153/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.