Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28440460 | 0.84 | DRD2 (0.46) | ABCB1PTGER1POLBRECQLDRD2 | |
| SCHEMBL11242408 | 0.81 | ACHE (0.45) | POLBHTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL30897244 | 0.81 | TLR9 (0.43) | PTGER1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL22440588 | 0.81 | TLR9 (0.43) | PTGER1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL15692718 | 0.80 | ACHE (0.46) | POLBHTR2AHTR2CHTR2BCRBN | |
| SCHEMBL25713351 | 0.78 | PTGER1 (0.35) | ABCB1PTGER1NPC1RAB9APOLB | |
| SCHEMBL15692861 | 0.77 | ACHE (0.46) | POLBHTR2AHTR2CHTR2BCRBN | |
| SCHEMBL8779044 | 0.75 | HTT (0.52) | PTGER1POLBRECQLDRD2HTR2A | |
| SCHEMBL15692838 | 0.74 | ACHE (0.49) | POLBHTR2AHTR2CHTR2BCRBN | |
| SCHEMBL11242839 | 0.73 | ALDH1A1 (0.43) | ABCB1HTR2AHTR2BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11685748-B2 | Spiro aromatic ring compound and application thereof | ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) | 2023-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11685748-B2 | Spiro aromatic ring compound and application thereof | PTPN1, PTPN11, PTPN5 | ABCB1 1389/4885PTGER1 2542/4885NPC1 1901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.