Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 5/20 | 0.43 |
| ▸ | RXRA | P19793 | 4/20 | 0.43 |
| ▸ | RXRG | P48443 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779163 | 0.85 | HTT (0.46) | HTTLMNASMN1; SMN2L3MBTL1NCOA3 | |
| SCHEMBL8778923 | 0.80 | DRD2 (0.41) | HTTLMNASMN1; SMN2L3MBTL1NCOA3 | |
| SCHEMBL5101144 | 0.77 | MRGPRX4 (0.74) | HTTLMNASMN1; SMN2L3MBTL1NCOA3 | |
| SCHEMBL31318410 | 0.77 | MRGPRX4 (0.74) | HTTLMNASMN1; SMN2L3MBTL1NCOA3 | |
| SCHEMBL3629080 | 0.76 | MRGPRX4 (0.62) | HTTLMNASMN1; SMN2L3MBTL1NCOA3 | |
| SCHEMBL25713331 | 0.75 | ABCB1 (0.43) | HTTCRBNIKZF3POLBRECQL | |
| SCHEMBL8778993 | 0.73 | MAOB (0.63) | SMN1; SMN2ALDH1A1DRD2HTR2AHTR2C | |
| SCHEMBL8779017 | 0.73 | MAOB (0.63) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL30112286 | 0.73 | HTT (0.56) | HTTLMNASMN1; SMN2L3MBTL1NCOA3 | |
| SCHEMBL34466766 | 0.73 | MAPT (0.45) | L3MBTL1MRGPRX4RXRBRXRARXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0606661-B1 | Octahydrophenanthrene derivatives and their use as NMDA-Antagonists | HOFFMANN LA ROCHE (CH) | 1997-03-12 | — | — | EP | disclosed |
| US-5385947-A | For prevention of nerve damage due to reduction of blood or oxygen supplies | HOFFMANN-LA ROCHE INC. (US) | 1995-01-31 | — | — | US | disclosed |
| EP-0606661-A1 | Octahydrophenanthrene derivatives and their use as NMDA-Antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1994-07-20 | — | — | EP | disclosed |