Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 4/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.44 |
| ▸ | PRKX | P51817 | 2/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.44 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4314660 | 0.83 | ROCK1 (0.46) | ROCK2ROCK1L3MBTL1HPGDMAOB | |
| SCHEMBL16834434 | 0.82 | L3MBTL1 (0.49) | ROCK2ROCK1L3MBTL1CLK2CLK4 | |
| SCHEMBL2914539 | 0.78 | ALDH1A1 (0.54) | HPGDALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2571077 | 0.76 | ROCK2 (0.74) | ROCK2ROCK1L3MBTL1CLK2CLK4 | |
| SCHEMBL31570079 | 0.75 | KMT2A (0.51) | L3MBTL1HPGDALDH1A1MAPTMEN1 | |
| SCHEMBL11576364 | 0.75 | KMT2A (0.51) | L3MBTL1HPGDALDH1A1MAPTMEN1 | |
| SCHEMBL2571902 | 0.74 | ROCK1 (0.44) | ROCK2ROCK1CLK2CLK4STK17A | |
| SCHEMBL11775480 | 0.74 | ALDH1A1 (0.50) | ROCK2HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL27792495 | 0.73 | GRM4 (0.49) | ROCK2ROCK1CLK2CLK4STK17A | |
| SCHEMBL16845742 | 0.73 | MAOB (0.48) | ROCK2ROCK1CLK2CLK4STK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633740-B1 | 5-(ACYLAMINO)INDAZOLE DERIVATIVES AS KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-11-09 | — | — | EP | disclosed |
| US-7560467-B2 | Indazolo-tetrahydropyrimidine-carboxamide derivative kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2009-07-14 | — | — | US | disclosed |
| US-20070099944-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099944-A1 | Chemical compounds | ROCK1, ROCK2, CIT | ROCK2 2/4885ROCK1 1/4885L3MBTL1 4139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.