Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13227770 | 1.00 | HDAC7 (0.43) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL20414883 | 0.86 | CA2 (0.44) | SPHK1MMP2MMP1MMP3CA1 | |
| SCHEMBL13351183 | 0.86 | CA2 (0.44) | SPHK1MMP2MMP1MMP3CA1 | |
| SCHEMBL17377402 | 0.85 | MMP3 (0.44) | SPHK1MMP2MMP1MMP3 | |
| SCHEMBL13494786 | 0.83 | MMP3 (0.47) | SPHK1MMP2MMP1MMP3 | |
| SCHEMBL13494792 | 0.83 | MMP3 (0.47) | SPHK1MMP2MMP1MMP3 | |
| SCHEMBL13958540 | 0.82 | HDAC7 (0.40) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL6848366 | 0.82 | HDAC7 (0.40) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL6848363 | 0.80 | HDAC7 (0.39) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL27285928 | 0.80 | SIRT6 (0.44) | HDAC7HDAC8HDAC6HDAC9HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107470-A1 | LONP1 INHIBITORS, USES AND METHODS | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-15 | — | — | WO | disclosed |