Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13958540 | 1.00 | HDAC7 (0.40) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL25719293 | 0.82 | HDAC7 (0.43) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL13227770 | 0.82 | HDAC7 (0.43) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL18293012 | 0.82 | FOLH1 (0.47) | — | |
| SCHEMBL22175192 | 0.82 | TDP1 (0.47) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL12766447 | 0.82 | HDAC7 (0.36) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL22622376 | 0.80 | HDAC7 (0.35) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL13400809 | 0.80 | SIRT6 (0.44) | DPP7SIRT6SIRT1CA1CA2 | |
| SCHEMBL22330612 | 0.80 | KISS1R (0.43) | CTSSCTSKHTR2AHRH1TSHR | |
| SCHEMBL13679232 | 0.80 | DPP7 (0.36) | HDAC7HDAC8HDAC6HDAC9HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6777535-B1 | USEFUL FOR TREATING CONDITIONS WHICH ARISE OR ARE EXACERBATED BY ANGIOGENESIS | ABBOTT LABORATORIES | 2004-08-17 | — | — | US | disclosed |