Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30308898 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1HTTLMNAKDM4E | |
| SCHEMBL25271035 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1HTTLMNAKDM4E | |
| SCHEMBL27272600 | 0.83 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1HTTLMNAKDM4E | |
| SCHEMBL25719380 | 0.83 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1HTTLMNAKDM4E | |
| SCHEMBL4095134 | 0.81 | KDM4E (0.69) | SMN1; SMN2ALDH1A1HTTLMNAKDM4E | |
| SCHEMBL3776763 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL25720020 | 0.77 | PTK2 (0.66) | ALDH1A1LMNAKDM4EGAAMAPK1 | |
| SCHEMBL2814765 | 0.76 | NCF1 (0.50) | SMN1; SMN2ALDH1A1HTTLMNAMAPT | |
| SCHEMBL4113454 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1HTTKDM4EMAPT | |
| SCHEMBL9404419 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1LMNAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208964-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | YUMANITY THERAPEUTICS, INC. | 2024-06-27 | — | — | US | disclosed |
| WO-2023107592-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208964-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | PNPO, DPYD, PYGB | SMN1; SMN2 7/4885ALDH1A1 945/4885HTT 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.