Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CD69 | Q07108 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25722481 | 1.00 | ALDH1A1 (0.42) | ALDH1A1THRBMAPK1LMNAKMT2A | |
| SCHEMBL22728166 | 0.88 | CA12 (0.33) | ALDH1A1THRBMAPK1LMNAKMT2A | |
| SCHEMBL8038560 | 0.86 | MAPK1 (0.48) | ALDH1A1THRBMAPK1LMNAKMT2A | |
| SCHEMBL22394176 | 0.86 | MAPK1 (0.48) | ALDH1A1THRBMAPK1LMNAKMT2A | |
| SCHEMBL8038552 | 0.86 | MAPK1 (0.48) | ALDH1A1THRBMAPK1LMNAKMT2A | |
| SCHEMBL18503678 | 0.83 | LMNA (0.40) | ALDH1A1THRBLMNAKMT2APOLB | |
| SCHEMBL25494618 | 0.82 | ALDH1A1 (0.46) | ALDH1A1THRBMAPK1POLBCD69 | |
| SCHEMBL16566075 | 0.81 | ALDH1A1 (0.40) | ALDH1A1THRBMAPK1CD69CA1 | |
| SCHEMBL20626631 | 0.81 | ALDH1A1 (0.56) | ALDH1A1THRBMAPK1LMNACD69 | |
| SCHEMBL12337162 | 0.81 | ALDH1A1 (0.56) | ALDH1A1THRBMAPK1LMNACD69 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230201183-A1 | METHODS TO SYNERGISTICALLY ENHANCE MULTIPLE CELLULAR PROTEOSTASIS PATHWAYS TO TREAT NEURODEGENERATION AND STORAGE DISEASES | NORTHWESTERN UNIVERSITY | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230201183-A1 | METHODS TO SYNERGISTICALLY ENHANCE MULTIPLE CELLULAR PROTEOSTASIS PATHWAYS TO TREAT NEURODEGENERATION AND STORAGE DISEASES | HSPA5, GBA1, SNCA | ALDH1A1 4027/4885THRB 3467/4885MAPK1 2264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.