Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | AMDHD2 | Q9Y303 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HK1 | P19367 | 3/20 | 0.39 |
| ▸ | HK2 | P52789 | 3/20 | 0.39 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22394176 | 1.00 | MAPK1 (0.48) | MAPK1AMDHD2ALDH1A1THRBLMNA | |
| SCHEMBL8038552 | 1.00 | MAPK1 (0.48) | MAPK1AMDHD2ALDH1A1THRBLMNA | |
| SCHEMBL25723433 | 0.86 | ALDH1A1 (0.42) | MAPK1ALDH1A1THRBLMNACYP2C19 | |
| SCHEMBL25722481 | 0.86 | ALDH1A1 (0.42) | MAPK1ALDH1A1THRBLMNACYP2C19 | |
| SCHEMBL18391246 | 0.86 | MAPK1 (0.49) | MAPK1AMDHD2ALDH1A1THRBLMNA | |
| SCHEMBL4314010 | 0.86 | MAPK1 (0.49) | MAPK1AMDHD2ALDH1A1THRBLMNA | |
| SCHEMBL26229737 | 0.86 | MAPK1 (0.49) | MAPK1AMDHD2ALDH1A1THRBLMNA | |
| SCHEMBL13240509 | 0.86 | MAPK1 (0.49) | MAPK1AMDHD2ALDH1A1THRBLMNA | |
| SCHEMBL25499747 | 0.86 | MAPK1 (0.49) | MAPK1AMDHD2ALDH1A1THRBLMNA | |
| SCHEMBL24133149 | 0.85 | LMNA (0.50) | MAPK1ALDH1A1THRBLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0560408-B1 | Enantio- and regioselective syntheses of organic compounds using enol esters as irreversible transacylation reagents | SEARLE & CO (US) | 2000-04-05 | — | — | EP | disclosed |
| US-5585252-A | CATALYTIC ACYLATION OF ALCOHOLS | G. D. SEARLE & CO. (US) | 1996-12-17 | — | — | US | disclosed |
| EP-0560408-A1 | Enantio- and regioselective syntheses of organic compounds using enol esters as irreversible transacylation reagents | G.D. SEARLE & CO. (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5106750-A | Enzymatic resolution of hydroxycyclopentenones using lipase | G. D. SEARLE & CO. (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0357009-A2 | Method of resolution of hydroxy-cyclopentenones using a lipase and transacylation agents | G.D. Searle & Co. (US) | 1990-03-07 | — | — | EP | disclosed |