Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.33 |
| ▸ | CA1 | P00915 | 5/20 | 0.33 |
| ▸ | CA2 | P00918 | 5/20 | 0.33 |
| ▸ | CA9 | Q16790 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | AMDHD2 | Q9Y303 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25723433 | 0.88 | ALDH1A1 (0.42) | CA12CA1CA2CA9LMNA | |
| SCHEMBL25722481 | 0.88 | ALDH1A1 (0.42) | CA12CA1CA2CA9LMNA | |
| SCHEMBL19320436 | 0.79 | ALDH1A1 (0.40) | LMNATHRBALDH1A1CYP2C19CYP2D6 | |
| SCHEMBL11181714 | 0.76 | FBP1 (0.47) | CA12CA1CA2CA9LMNA | |
| SCHEMBL22394176 | 0.75 | MAPK1 (0.48) | LMNATHRBALDH1A1AMDHD2CYP2C19 | |
| SCHEMBL8038552 | 0.75 | MAPK1 (0.48) | LMNATHRBALDH1A1AMDHD2CYP2C19 | |
| SCHEMBL8038560 | 0.75 | MAPK1 (0.48) | LMNATHRBALDH1A1AMDHD2CYP2C19 | |
| SCHEMBL1499315 | 0.74 | — | — | |
| SCHEMBL13205051 | 0.73 | THRB (0.47) | CA12CA1CA2CA9LMNA | |
| SCHEMBL18503678 | 0.72 | LMNA (0.40) | CA12CA1CA2CA9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377510-B1 | GALNAC CLUSTER PHOSPHORAMIDITE | HOFFMANN LA ROCHE (CH) | 2020-12-02 | — | — | EP | disclosed |