Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL57463 | 0.85 | MPO (0.56) | MPO | |
| SCHEMBL18621746 | 0.78 | MPO (0.52) | MPOTAAR1MAP4K4 | |
| SCHEMBL18585821 | 0.69 | MPO (0.65) | MPO | |
| SCHEMBL7437052 | 0.68 | TAAR1 (0.68) | TAAR1PTGS1PTGS2MAOBAOC3 | |
| Sampirtine SCHEMBL1230637 | 0.68 | MPO (0.49) | MPOIDO1LOXL2 | |
| Sampirtine SCHEMBL29973209 | 0.68 | MPO (0.49) | MPOIDO1LOXL2 | |
| SCHEMBL28520283 | 0.68 | TAAR1 (0.40) | DHFRTAAR1PTGS1PTGS2MAOB | |
| SCHEMBL3364178 | 0.67 | GFER (0.74) | TAAR1MAOBAOC3LOXL2 | |
| Sampirtine SCHEMBL10569152 | 0.67 | MPO (0.48) | MPOIDO1LOXL2 | |
| SCHEMBL18620550 | 0.66 | NOS2 (0.42) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383268-A1 | Pyrazolylaminopyridine derivatives useful as kinase inhibitors | AstraZeneca AB (SE) | 2011-11-02 | — | — | EP | disclosed |