Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25745966 | 0.82 | EGLN2 (0.39) | HDAC1EGLN2EGLN1 | |
| SCHEMBL25745974 | 0.81 | DYRK1A (0.41) | SMN1; SMN2LMNANAMPT | |
| SCHEMBL21515026 | 0.77 | FPR2 (0.66) | — | |
| SCHEMBL21515061 | 0.73 | CYP3A4 (0.47) | SMN1; SMN2NPC1EGLN2EGLN1KDM4E | |
| SCHEMBL21515083 | 0.71 | CYP3A4 (0.48) | SMN1; SMN2EPHX2KDM4E | |
| SCHEMBL22854371 | 0.71 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTNPC1RAB9ALMNA | |
| SCHEMBL21515092 | 0.71 | CYP1A2 (0.45) | SMN1; SMN2NPC1HDAC1HDAC2KDM4E | |
| SCHEMBL31069204 | 0.69 | HTT (0.44) | SMN1; SMN2RECQLHTTNPC1RAB9A | |
| SCHEMBL31348094 | 0.67 | ALDH1A1 (0.43) | SMN1; SMN2 | |
| SCHEMBL19435882 | 0.66 | BACE1 (0.41) | SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781554-B1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | THOMAS HELLEDAYS STIFTELSE FOER MEDICINSK FORSKNING (SE) | 2023-06-28 | — | — | EP | disclosed |