Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 10/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.39 |
| ▸ | FPR2 | P25090 | 3/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.33 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25745901 | 0.82 | SMN1; SMN2 (0.42) | EGLN2EGLN1HDAC1 | |
| SCHEMBL25745892 | 0.80 | NAMPT (0.41) | HDAC3HDAC1ALDH1A1 | |
| SCHEMBL25745974 | 0.73 | DYRK1A (0.41) | FPR2BACE1ALDH1A1 | |
| SCHEMBL21515061 | 0.68 | CYP3A4 (0.47) | EGLN2EGLN1ALDH1A1 | |
| SCHEMBL21515083 | 0.67 | CYP3A4 (0.48) | ALDH1A1 | |
| SCHEMBL21515092 | 0.66 | CYP1A2 (0.45) | HDAC3HDAC1ALDH1A1 | |
| SCHEMBL25745634 | 0.64 | FPR2 (0.72) | EGLN2EGLN1FPR2MTHFD1MTHFD2 | |
| SCHEMBL107626 | 0.62 | BACE1 (0.42) | BACE1ALDH1A1 | |
| SCHEMBL19435882 | 0.62 | BACE1 (0.41) | FPR2MTHFD1MTHFD2BACE1ALDH1A1 | |
| SCHEMBL10083553 | 0.61 | KDM4E (0.51) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781554-B1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | THOMAS HELLEDAYS STIFTELSE FOER MEDICINSK FORSKNING (SE) | 2023-06-28 | — | — | EP | disclosed |