Sugi Predict

Sugi Predict / Compounds / SCHEMBL257482

SCHEMBL257482

SCHEMBL257482

O=C(O)COc1ccccc1F

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.61
▸ SMN1; SMN2 Q16637 2/20 0.61
▸ POLB P06746 1/20 0.61
▸ GLA P06280 1/20 0.61
▸ HPGD P15428 4/20 0.58
▸ PTGDR2 Q9Y5Y4 2/20 0.58
▸ KDM4E B2RXH2 2/20 0.58
▸ ALDH1A1 P00352 2/20 0.58
▸ TDP1 Q9NUW8 1/20 0.58
▸ FFAR1 O14842 1/20 0.56
▸ ALOX15 P16050 2/20 0.55
▸ PKM P14618 1/20 0.54
▸ CXCL8 P10145 1/20 0.54
▸ LMNA P02545 2/20 0.54
▸ FKBP1A P62942 1/20 0.54
▸ ADRB2 P07550 1/20 0.53
▸ MRGPRX4 Q96LA9 1/20 0.51
▸ MEN1 O00255 2/20 0.51
▸ KMT2A Q03164 2/20 0.51
▸ HSD17B10 Q99714 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29757370 1.00 L3MBTL1 (0.61) L3MBTL1SMN1; SMN2POLBGLAHPGD
SCHEMBL340762 0.85 L3MBTL1 (0.80) L3MBTL1SMN1; SMN2POLBGLAHPGD
SCHEMBL29682135 0.85 L3MBTL1 (0.80) L3MBTL1SMN1; SMN2POLBGLAHPGD
SCHEMBL10563845 0.84 FFAR1 (0.54) L3MBTL1SMN1; SMN2POLBGLAHPGD
Ammonia Solution, Strong SCHEMBL28240461 0.83 L3MBTL1 (0.77) L3MBTL1SMN1; SMN2POLBGLAHPGD
SCHEMBL15197111 0.82 HPGD (0.55) L3MBTL1SMN1; SMN2POLBHPGDKDM4E
SCHEMBL9127892 0.82 HPGD (0.55) L3MBTL1SMN1; SMN2HPGDKDM4EALDH1A1
SCHEMBL11212899 0.82 HPGD (0.55) L3MBTL1SMN1; SMN2HPGDKDM4EALDH1A1
SCHEMBL11212903 0.82 HTT (0.61) L3MBTL1SMN1; SMN2HPGDKDM4EALDH1A1
SCHEMBL18864120 0.82 KDM4E (0.51) L3MBTL1SMN1; SMN2POLBGLAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010142652-A1 IMIDAZOBENZAZEPINE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) DISEASES GLAXO GROUP LIMITED (GB) 2010-12-16 — — WO claimed
US-7015247-B2 Ibuprofen-aspirin, hydroxymethylacylfulvene analogs and L-sugar illudin analogs GUTTAG ALVIN 2006-03-21 — — US claimed
US-20030008833-A1 Ibuprofen-aspirin, hydroxymethylacylfulvene analogs and L-sugar illudin analogs GUTTAG ALVIN (US) 2003-01-09 — — US claimed
US-20020065254-A1 Ibuprofen-aspirin and hydroxymethylacylfulvene analogs GUTTAG ALVIN (US) 2002-05-30 — — US claimed
EP-3704094-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-11 — — EP disclosed
US-12497636-B2 Recombinant Saccharomyces cerevisiae cells for cannabinoid production NATIONAL UNIVERSITY OF SINGAPORE (SG) 2025-12-16 — — US disclosed
US-20250122188-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2025-04-17 — — US disclosed
US-20240166652-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2024-05-23 — — US disclosed
EP-4356971-A2 MODULATORS OF THE INTEGRATED STRESS PATHWAY Calico Life Sciences LLC (US) 2024-04-24 — — EP disclosed
US-20240093253-A1 SUSTAINABLE PRODUCTION OF CANNABINOIDS FROM SIMPLE PRECURSOR FEEDSTOCKS USING SACCHAROMYCES CEREVISIAE NATIONAL UNIVERSITY OF SINGAPORE (SG) 2024-03-21 — — US disclosed
EP-3470407-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2024-01-24 — — EP disclosed
US-20230322804-A1 REAGENTS FOR REVERSIBLY PROTECTING BIOLOGICAL MOLECULES bioMérieux (FR) 2023-10-12 — — US disclosed
EP-0413750-A1 RENIN INHIBITORY PEPTIDES CONTAINING A SUBSTITUTED PHENOXYACETYLE GROUP THE UPJOHN COMPANY (US) 1991-02-27 — — EP disclosed
WO-1989010920-A1 RENIN INHIBITORY PEPTIDES CONTAINING A SUBSTITUTED PHENOXYACETYLE GROUP THE UPJOHN COMPANY (US) 1989-11-16 — — WO disclosed
US-4845127-A ANTIBESITY ELI LILLY AND COMPANY (US) 1989-07-04 — — US disclosed
US-4391826-A DIETETICS ELI LILLY AND COMPANY (US) 1983-07-05 — — US disclosed
EP-0007204-B1 PHENETHANOLAMINES, THEIR FORMULATIONS, USE AND PREPARATION ELI LILLY AND COMPANY (US) 1982-11-24 — — EP disclosed
EP-0007204-A1 Phenethanolamines, their formulations, use and preparation ELI LILLY AND COMPANY (US) 1980-01-23 — — EP disclosed
US-4086240-A 1-Thiazolyl-5-phenoxy and phenylthioalkanoyloxyimidazolidinones VELSICOL CHEMICAL CORPORATION (US) 1978-04-25 — — US disclosed
US-4053480-A 1-THIADIAZOLYL-5-PHENOXY- AND PHENYLTHIOALKANOYLOXY IMIDAZOLIDINONES VELSICOL CHEMICAL CORPORATION (US) 1977-10-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250122188-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 L3MBTL1 1651/4885SMN1; SMN2 2486/4885POLB 1764/4885
US-20230322804-A1 REAGENTS FOR REVERSIBLY PROTECTING BIOLOGICAL MOLECULES AZI2, TPMT, CA12 L3MBTL1 3548/4885SMN1; SMN2 4180/4885POLB 943/4885
US-20240166652-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 L3MBTL1 1651/4885SMN1; SMN2 2486/4885POLB 1764/4885
US-20020065254-A1 Ibuprofen-aspirin and hydroxymethylacylfulvene analogs PTGES3, HPGDS, PTGES L3MBTL1 1730/4885SMN1; SMN2 1900/4885POLB 2611/4885
US-20030008833-A1 Ibuprofen-aspirin, hydroxymethylacylfulvene analogs and L-sugar illudin analogs GALE, TPT1, HPSE L3MBTL1 46/4885SMN1; SMN2 1639/4885POLB 3411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.