Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.66 |
| ▸ | RAB9A | P51151 | 7/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.60 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25766322 | 0.90 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2TRPV1ACKR3 | |
| SCHEMBL19058585 | 0.84 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2TRPV1CHRNA7 | |
| SCHEMBL24052027 | 0.84 | RAB9A (0.71) | NPC1RAB9ASMN1; SMN2TRPV1CHRNA7 | |
| SCHEMBL25754145 | 0.80 | RAB9A (0.66) | NPC1RAB9ASMN1; SMN2TRPV1CHRNA7 | |
| SCHEMBL1105986 | 0.80 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TRPV1CHRNA7 | |
| SCHEMBL4988297 | 0.79 | TRPV1 (0.88) | NPC1RAB9ASMN1; SMN2TRPV1HDAC6 | |
| SCHEMBL20481983 | 0.79 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2TRPV1ALDH1A1 | |
| SCHEMBL2970236 | 0.78 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2TRPV1CHRNA7 | |
| SCHEMBL31120903 | 0.78 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2TRPV1CHRNA7 | |
| SCHEMBL24052275 | 0.77 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2TRPV1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240026358-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2024-01-25 | — | — | US | disclosed |
| US-20230203484-A1 | DOUBLE STRANDED OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO | WAVE LIFE SCIENCES LTD. (SG) | 2023-06-29 | — | — | US | disclosed |
| US-20230203087-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203087-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | RNGTT, NSUN2, ALKBH1 | NPC1 4128/4885RAB9A 4490/4885SMN1; SMN2 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.