Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27741570 | 0.80 | EGFR (0.51) | METPDE10AKLKB1KLK1 | |
| SCHEMBL28205301 | 0.77 | L3MBTL1 (0.51) | METALDH1A1MAPTATMKDM4E | |
| SCHEMBL27022434 | 0.77 | ALDH1A1 (0.56) | METALDH1A1PDE10ANPC1RAB9A | |
| SCHEMBL1163489 | 0.77 | MET (0.41) | METALDH1A1MAPTATMKDM4E | |
| SCHEMBL28864698 | 0.77 | NPC1 (0.35) | METALDH1A1KDM4EHTTNPC1 | |
| SCHEMBL27997631 | 0.74 | ALDH1A1 (0.49) | METALDH1A1MAPTATMKDM4E | |
| SCHEMBL28262231 | 0.74 | ALDH1A1 (0.49) | METALDH1A1MAPTATMKDM4E | |
| SCHEMBL29520054 | 0.74 | CHRNA7 (0.44) | ALDH1A1 | |
| SCHEMBL28263726 | 0.74 | PDE10A (0.46) | METALDH1A1MAPTATMKDM4E | |
| SCHEMBL27824234 | 0.73 | MET (0.53) | METALDH1A1MAPTATMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102548995-B | heterocyclic hydrazone compounds and their use for treating cancer and inflammation | NOVARTIS AG | 2015-01-28 | — | — | CN | disclosed |
| CN-102574853-B | Heterocyclic oxime compounds | NOVARTIS AG | 2015-01-21 | — | — | CN | disclosed |
| EP-2018383-B1 | TRIAZOLOPYRAZINE DERIVATIVES USEFUL AS ANTI-CANCER AGENTS | PFIZER PROD INC (US) | 2011-11-09 | — | — | EP | disclosed |
| CN-101443331-A | Triazolopyrazine derivatives useful as anti-cancer agents | PFIZER PROD INC (US) | 2009-05-27 | — | — | CN | disclosed |