Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2575351 | 0.77 | MET (0.51) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL3712064 | 0.76 | KDM4E (0.43) | NPC1LMNAADORA3ADORA2AADORA1 | |
| SCHEMBL28864802 | 0.75 | LOXL2 (0.42) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL1163489 | 0.74 | MET (0.41) | NPC1KDM4EMETALDH1A1HTT | |
| SCHEMBL3717020 | 0.72 | CCR1 (0.42) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL29870041 | 0.72 | MET (0.43) | LMNAADORA3ADORA2AADORA1MET | |
| SCHEMBL28864820 | 0.72 | MET (0.43) | LMNAADORA3ADORA2AADORA1MET | |
| SCHEMBL29869683 | 0.72 | KDM4E (0.40) | NPC1RAB9AADORA3ADORA2AADORA1 | |
| SCHEMBL28047795 | 0.72 | L3MBTL1 (0.43) | NPC1RAB9AL3MBTL1 | |
| SCHEMBL29520054 | 0.71 | CHRNA7 (0.44) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107312009-B | Quinoline compound, preparation method, intermediate, pharmaceutical composition and application thereof | 上海医药集团股份有限公司 | 2022-09-20 | — | — | CN | disclosed |