Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2568247 | 0.92 | HTR7 (0.42) | KMT2AMEN1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL2530664 | 0.86 | GAA (0.47) | ALDH1A1HTTMAPTNPC1RAB9A | |
| SCHEMBL2532947 | 0.84 | RAB9A (0.44) | KMT2AMEN1SMN1; SMN2TP53MAPT | |
| SCHEMBL2530890 | 0.84 | KMT2A (0.43) | KDM4EKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL2527836 | 0.82 | F10 (0.40) | ALDH1A1SMN1; SMN2TP53RAB9AGAA | |
| SCHEMBL12219890 | 0.81 | KMO (0.43) | KDM4EKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL2535130 | 0.81 | KMT2A (0.46) | NR1H4KMT2AMEN1TP53POLB | |
| SCHEMBL2532410 | 0.81 | NR4A1 (0.33) | ITGB3ITGAVKDM4EKMT2AMEN1 | |
| SCHEMBL2530126 | 0.80 | ALDH1A1 (0.40) | KDM4EKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL2531699 | 0.80 | KDM1A (0.47) | NR1H4HDAC1HDAC8HDAC6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558449-A1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011128251-A1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-20 | — | — | WO | disclosed |