Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17865779 | 0.85 | LMNA (0.58) | HDAC1POLBMAPTHTTLMNA | |
| SCHEMBL27062480 | 0.82 | HDAC1 (0.51) | HDAC1HDAC6ALDH1A1POLBTDP1 | |
| SCHEMBL3837433 | 0.80 | RAB9A (0.53) | HDAC1HDAC6ALDH1A1POLBTDP1 | |
| SCHEMBL28763295 | 0.80 | HDAC6 (0.51) | HDAC1HDAC6MAPTLMNAHDAC8 | |
| SCHEMBL29706078 | 0.80 | HDAC6 (0.51) | HDAC1HDAC6MAPTLMNAHDAC8 | |
| SCHEMBL2522600 | 0.79 | LMNA (0.53) | HDAC1ALDH1A1POLBMAPTHTT | |
| SCHEMBL13701704 | 0.79 | LMNA (0.56) | ALDH1A1POLBMAPTHPGDHTT | |
| SCHEMBL10520508 | 0.78 | LMNA (0.53) | HDAC1ALDH1A1POLBMAPTHPGD | |
| SCHEMBL20964361 | 0.78 | LMNA (0.49) | HDAC1ALDH1A1POLBMAPTHPGD | |
| SCHEMBL13701770 | 0.78 | HDAC2 (0.59) | HDAC6MAPTHPGDHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240026358-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2024-01-25 | — | — | US | disclosed |
| US-20230203484-A1 | DOUBLE STRANDED OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO | WAVE LIFE SCIENCES LTD. (SG) | 2023-06-29 | — | — | US | disclosed |